Studies on the Chemical Modification of Monensin. IV. Synthesis, Sodium Ion Permeability, and Biological Activity of 7-O-Acyl-and 7-O-Alkylmonensins
スポンサーリンク
概要
- 論文の詳細を見る
7-O-Acyl-(4a-e) and 7-O-alkylmonensins (5a-d) were prepared from monensin (1). Their lipophilicity, sodium ion permeability in human erthrocysts, antibacterial activity and effect on rat tail artery were examined. There was a correlation between lipophilicity and sodium ion permeability as well as between lipophilicity and antibacterial activity.We also found that the compound having larger sodium ion permeability, showed stronger contraction of rat tail artery. 7-O-Benzylmonensin (5c) exhibited higher lipophilicity and larger sodium ion permeability than monensin (1)among the tested monesin derivatives. In addition, antibacterial activity and contractile effect on rat tail artery of 5c were comparable to those of 1.
- 社団法人日本薬学会の論文
- 1992-09-25
著者
-
植田 泰誠
Faculty of Pharmaceutical Sciences, Nagoya City University
-
村上 啓寿
Faculty of Pharmaceutical Sciences, Nagoya City University
-
榊原 仁作
Faculty of Pharmaceutical Sciences, Nagoya City University
-
中村 明人
Faculty Of Pharmaceutical Sciences
-
榊原 仁作
名市大院薬
-
榊原 仁作
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
永井 慎一
名市大薬
-
村上 啓寿
(Present address)Kyoto Pharmaceutical University
-
高橋 正
Faculty of Pharmaceutical Sciences, Nagoya City University
-
永井 愼一
Faculty of Pharmaceutical Sciences, Nagoya City University
-
浅野 正久
Department of Pharmacology, Nagoya City University Medical School
-
MALHAN Renu(neeCHOPRA)
Faculty of Pharmaceutical Sciences
-
浅野 正久
School of Medicine Nagoya City University
-
榊原 仁作
名古屋市大 大学院 薬
-
村上 啓寿
Faculty Of Pharmaceutical Sciences Osaka University
-
浅野 正久
Department Of Pharmacology Nagoya City University Medical School
-
永井 愼一
Faculty Of Pharmaceutical Sciences Nagoya City University
-
植田 泰誠
Faculty Of Pharmaceutical Sciences Nagoya City University
-
榊原 仁作
Faculty Of Pharmaceutical Sciences Nagoya City University
-
村上 啓寿
Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address)kyoto Pharmaceutical Univ
-
高橋 正
Faculty Of Pharmaceutical Sciences Nagoya City University
関連論文
- ビス(P-クロルフェニル)カルピノール系殺ダニ剤のガスクロマトグラフィーによる定量
- Novel Annelations of Xanthines by the Reaction of 8-Aminoxanthines with Dimethyl Acetylene-dicarboxylate
- 新しい入試制度を体験して
- Synthesis of Isoselenazolo- or Isothiazolo[4,3-e][1,4]diazepines
- A Novel Cyclononatriene System from N-Veratrylethanolamine-N-tosylate
- 105(P-62) Monensin二価誘導体のイオン輸送能とコンフォメーションに関する研究(ポスター発表の部)
- 58(P-33) ポリエーテル抗生物質monensinおよび誘導体のNMRを用いた溶液中の立体配座推定へのアプローチ : Long range C-H結合定数を利用して(ポスター発表の部)
- 113(P48) イオノフォア抗生物質Monensinの化学修飾とイオン輸送活性(ポスター発表の部)
- Chemistry of Cyclotriveratrylene. I. Formation of Cyclotriveratrylene from Veratrylamine N-Tosylates
- Ferricyanide Oxidation of dl-N-Methylisosalsoline and Its Methiodide
- Ferricyanide Oxidation of Corypalline and Its Methiodide
- これからの図書館
- 123(P70) イオノフォア抗生物質Monensinの化学修飾とイオン輸送活性(ポスター発表の部)
- NOVEL ANTIOXIDANTS FROM ROASTED PERILLA SEED
- Studies on Chemical Modification of Monensin. V. Synthesis, Sodium Ion Permeability, Antibacterial Activity, and Crystal Structure of 7-O-(4-Substituted benzyl)monensins
- Studies on Cardiac Ingredients of Plants. XI. Synthesis of New Bufotoxin Homologues Utilizing Scillarenin (the Genuine Aglycone of Proscillaridin), and Their Biological Activities
- Mechanism of an Early Lysis by Fatty Acids from Axenic Phormidium tenue (Musty Odor-Producing Cyanobacterium) and Its Growth Prolongation by Bacteria
- ENZYMATIC REGIOSELECTIVE ACYLATION OF 3-O-β-D-GALACTOPYRANOSYL-SN-GLYCEROL BY ACHROMOBACTER SP. LIPASE
- Auto-Growth Inhibitory Substance from the Fresh-Water Cyanobacterium Phormidium tenue
- Isolation and Identification of Anti-tumor-Promoting Principles from the Fresh-Water Cyanobacterium Phormidium tenue
- Studies on Glycolipids. VII. Isolation of Two New Sulfoquinovosyl Diacylglycerols from the Green Alga Chlorella vulgaris
- Studies on Glycolipids. VI. New Acyl-Distributed Glyceroglycolipids from the Nitrogen-Fixing Cyanobacterium Anabaena flos-aquae f. flos-aquae
- CARDIAC GLYCOSIDE-INDUCED ELEVATION OF INTRACELLULAR Na^+ ION CONCENTRATION IN HUMAN ERYTHROCYTES STUDIED BY ^Na NMR SPECTROSCOPY : RELATIONSHIP BETWEEN INOTROPY SPEED AND ELEVATION RATE OF INTRACELLULAR Na^+ ION CONCENTRATION
- Ring Transformation Medeated by Lewis Acids and Oxidizing Agents.Synthesis of 2-Methoxy-1H-imidazole from 5-Aminopyrimidin-4(3H)-one
- 強心性植物成分の研究(第10報)Tetrahydroproscillaridinの硝酸エステル体の合成とその薬理作用
- Studies on the Chemical Modification of Monensin. IV. Synthesis, Sodium Ion Permeability, and Biological Activity of 7-O-Acyl-and 7-O-Alkylmonensins
- Studies on Cardiac Ingredients of Plants. IX. Chemical Transformation of Proscillaridin by Utilizing Its 1,4-Cycloadducts as Key Compounds and Biological Activities of Their Derivatives
- A NOVEL GLYCEROGLYCOLIPID FROM THE NITROGEN-FIXING CYANOBACTERIUM ANABAENA FLOS-AQUAE F. FLOS-AQUAE
- The Oxidized Products of 8-Methoxypsoralen (8-MOP) with H_2O_2-NaOCl
- Studies on Glycolipids. III. Glyceroglycolipids from an Axenically Cultured Cyanobacterium, Phormidium tenue
- 強心性植物成分の研究(第8報)強心配糖体Proscillaridinの硝酸エステル体の合成とその薬理作用
- Utilization of Organoselenium Compounds. II. Reaction of Fused Isoselenazoles with Alkylamines(Organic,Chemical)
- Studies on the chemical Modification of Monensin. III. Synthesis and Sodium Ion transport Activity of macrocylic Monenslamino Acid-1,29-lactones
- Studies on the Chemical Modification of Monensin. II. : Measurement of Sodium Ion Permeability of Monensylamino Acids Using Sodium-23 Nuclear Magnetic Resonance Spectroscopy
- Studies on the Chemical Modification of Monensin. I. : Synthesis and Crystal Stuructures of NaBr Complexes of Monensylamino Acids
- Ring Transformation of a Diterpenoid Grayanol Derivative into 1-epi-Leucothol
- Reaction of Grayanotoxin-II with Lead Tetraacetate
- 入試制度と学生層の変化(入試制度と薬学教育)
- Studies on Cardiac Ingredients of Plants. V. : Chemical Transformation of Proscillaridin and Biological Activities of Derivaties
- Studies on Cardiac Ingredients of Plants. III. Structural Confirmation and Biological Activity of Reduced Proscillaridins(Organic,Chemical)
- ネジキLyonia ovalifolia DRUDE var.elliptica HAND.-MAZZ.の成分研究(第20報)Triterpenoid Glucoside, Lyofolic Acidの構造 その4 Protolyofoligenic Acidの構造
- ネジキLyonia ovalifolia DRUDE var.elliptica HAND.-MAZZ.の成分研究(第19報)Triterpenoid Glucoside, Lyofolic Acidの構造 その3 Lyofoligenic Acidの構造
- Correlation of Protolyofoligenic Acid with Cycloartenol
- ホツツジTripetaleia paniculata SIEB.et.ZUCC.の成分研究(第5報)花の成分と材の成分(その3)について
- ネジキLyonia ovalifolia DRUDE var. elliptica HAND.-MAZZ.の成分研究(第18報)Diterpenoid, Lyoniol-Dの構造およびLyoniol-A(Lyoniatoxin)とGrayanotoxin-Iの関連について
- 含窒素Triterpene誘導体の合成研究(第8報)ベツリン酸およびオレアノール酸誘導体
- ホツツジTripetaleia paniculata SIEB.et ZUCC.の成分研究(第4報)材の成分について その2 Lyonisideの構造
- ネパール産Lyonia ovalifolia DRUDE葉の成分研究
- 含窒素Triterpene誘導体の合成研究(第2報)A環に数種の含窒素環を縮合させたTriterpene誘導体
- Structure-Activity Relationship of Lyoniol-A and Related Compounds in Association with the Excitatory Effect on Muscle Spindle Afferents
- Correlation of Lyoniol-A (Lyoniatoxin) with Grayanotoxin-I
- 有用化合物への変換を目指した天然物の化学修飾 : イオノフォア抗生物質Monensinの化学修飾
- 94(P31) 油糧種子に含有される抗酸化物質の研究 : ベニバナ油粕及び綿実油粕に含有される抗酸化物質の探索(ポスター発表の部)
- Synthesis of Pyrazolone Derivatives. XXXIX. Synthesis and Analgesic Activity of Pyrano [2,3-c] pyrazoles
- Studies on Synthetic Methods for 5-Amino-4 (3H)-pyrimidones. I. A Novel Ring Expansion Reaction of 4-Aminoantipyrines to 5-Amino-4 (3H)-pyrimidones
- Synthesis of Organometallic Complexes. II. Reaction of (Ferrocenylmethyl) trimethylammonium Iodide with Thiol-Type Nucleophiles
- Synthesis of Polycyclines. I. Diels-Alder Reaction of 5-Nitronaphthoquinone with Unsymmetrical Butadienes
- Synthesis of Pyrazolone Derivatives. XXXI. Asynmetric Synthesis of 3a-Alkyl-3,3a, 4,5,6,7-hexahydro-2H-indazol-3-ones
- Synthesis of Pyrazolone Derivatives. XXX. Synthesis of Pyrazolo [3,4-b] [1,4] oxazepines
- Synthetic Studies on Pyridoxine Derivatives. II. Synthesis of 3-(3-Hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl) methyl-4-methyl-5-substitutedthiazoline-2-thiones
- Studies on Cardiac Ingredients of Plants. VII : Chemical Transformation of Proscillaridin by Means of the Diels-Alder Reaction and Biological Activities of Its Derivatives
- PHOTOCHEMICAL TRANSFORMATION OF BUFADIENOLIDE
- Syntheses of Dihydrodioxepinopyridines, Dihydrodioxocinopyridines, and a Dihydrooxazepinopyridine
- Studies on the Chemical Transformations of Rotenoids. IV. : Synthesis of Novel Benzofuro[2,3-d]pyridazines Fused with Tetrazole, 1,2,4-Triazole and 1,2,4-Triazine
- Transformation of Pyrazolo [3,4-c] [1,5] benzothiazepines into Quinolines
- 新規複素環キノン"Benzo[g]pyrido[2,1-b]quinazoline-6,11-dioneおよびBenzo[g]pyrazolo[3,2-b]quinazoline-5,10-diones"の合成
- ナフトキノンを原料とするBenzo[α]phenazine誘導体の合成とその抗菌活性
- Synthesis of Coumarins by Nucleophilic Denitrocyclization Reaction(Organic,Chemical)
- Synthesis of Imidazo[4,5-c][1,2,6]thiadiazine 2-Oxides from Hydrolytes of Xanthines and Determination of Their Vasodilating Activity
- Synthesis of Imidazo[4,5-e][1,4]diazepine and Imidazo[4,5-e][1,4]-oxazepine Derivatives Using Caffeidine, a Hydrolysis Product of Caffeine
- Studies on Xanthine Derivatives. II. : Synthesis of 1,2,3,7-Tetrahydro-6H-purin-6-ones from Xanthine Hydrolyzates
- SEVEN NEW MONOGALACTOSYL DIACYLGLYCEROLS ISOLATED FROM THE AXENIC CYANOBACTERIUM PHORMIDIUM TENUE
- AN AUTOLYTIC SUBSTANCE IN A FRESHWATER CYANOBACTERIUM PHORMIDIUM TENUE
- Syntheses, Antitumor Activity and Vascular Relaxing Effect of Purino[7,8-g]-6-azapteridines and [1,2,4]Triazino-[3,2-f]purines(Organic,Chemical)
- 強心性植物成分の研究 : キサンチン誘導体の構造変換と生理活性について
- Synthesis of 5-Amino-4 (3H)-pyrimidinones. II. Synthesis of 5-Acyl- and 5-Alkylamino-3-phenyl-6-methyl-4 (3H)-pyrimidinones and Determination of Their Analgesic and Antiinflammatory Activities
- OCCURRENCE OF PIEROSIDE C, A GRAYANOTOX-9-ENE DERIVATIVE, IN PIERIS JAPONICA
- ツツジ科植物に含まれるジテルペノイド
- アセビPieris japonica葉の成分研究.新ジテルペンAsebotoxin-Xおよび新ジテルペン配糖体Pieroside Aの単離と構造決定
- Carbon-13 Nuclear Magnetic Resonance Spectral Assignments of Grayanotoxin-I
- Structure of Vaccinoside
- Structure of Lyoniol-D
- 公開講座を語る
- Stereostructure of Lyoniol-A (Lyoniatoxin) and Grayanotoxin-II
- Structure of Innovanoside
- Structure of Lyoniol-A (Lyoniatoxin)
- 醤油より4-Hydroxy-5-Methyl-3(2H)-Furanone(HMF)の簡易分離法
- NOVEL UTILIZATION OF ORGANOSELENIUM COMPOUNDS. I. A FACILE TRANSFORMATION OF FUSED ISOSELENAZOLES TO FUSED PYRIDINES
- NOVEL RING TRANSFORMATION OF 5-AMINO-4 (3H)-PYRIMIDINONES INTO IMIDAZOLES AND IMIDAZOLES INTO A 1,2,4-TRIAZINE
- AN UNUSUAL TRANSFORMATION OF 5-AMINO-6-METHYL-3-PHENYL-4 (3H)-PYRIMIDONE WITH SELENIUM DIOXIDE : X-RAY CRYSTAL STRUCTURE OF 3-PHENYLCARBAMOYL-4-METHYL-1,2,5-SELENADIAZOLE
- 第12回IUPAC天然物化学シンポジウム
- 2,6-ジブロムキノンクロルイミドによるカーバメート系殺虫剤の比色定量法
- 強心性植物成分の研究--ジヒドロウワバインの構造と生理活性について
- 大学図書館にはなるべく多くの一次資料を揃えたい(情報化時代を迎えた薬学図書館のあり方)
- 研究年報を生かすには……(大学紀要・研究所年報を考える)
- 秋, 各支部で盛大な支部大会を(支部活動への希望と意見)
- 有機化合物構造決定入門書
- 有機化学の教科書あれこれ
- 二本立ては止めて, 会場設営・会費徴収に工夫を(年会懇親会のあり方)
- 塩化パラジウムとp-ニトロソN,N-ジエチルアニリンを利用した含硫黄有機リン系殺虫剤の比色定量