抗腫瘍性抗生物質の骨格変換に関する研究(第2報)Naphtho[2,3-g]-quinolineおよびNaphtho[2,3-g]quinoxaline誘導体の合成

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概要

• 論文の詳細を見る

• As the initial study of variations of skeletons of antitumor antibiotics, simple synthesis of naphtho [2,3-g] quinolines (IIIa, b, VIII) and naphtho [2,3-g] quinoxalines (XIIIa, b), which are novel heterocyclic ring systems, was carried out by Diels-Alder reaction of 1,2-dimethylenecyclohexane with quinoline-5,8-diones (Ia-c) or quinoxaline-5,8-diones (IIa, b). Air oxidation of these Diels-Alder adducts gave tetrahydro naphtho [2,3-g] quinolines (IVa, b, IX) and tetrahydronaphtho [2,3-g] quinoxalines (XVa, b). The Diels-Alder adducts and aromatized compounds were converted into the corresponding diacetoxynaphtho [2,3-g] quinolines (VI, VII, X) and diacetoxynaphtho [2,3-g] quinoxalines (XVII, XVIII).

• 公益社団法人日本薬学会の論文
• 1981-09-25

著者

• 織田 範一

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 小林 和弘

  名古屋市立大学薬学部

• 伊藤 磯雄

  名古屋市立大学薬学部

• 織田 範一

  名古屋市立大学薬学部

• 織田 範一

  Faculty Of Pharmaceutical Sciences Nagoya City University

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