Diphenylmethane誘導体の研究(第4報)Diphenylglycine誘導体の合成
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Some derivatives of 2-chlorophenyl-2-dimethoxyphenylglycine were synthesized. N-Acetyl-2-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl) glycine (VIII) was cyclized to 4,4-diphenyloxazolone (IX) on heating with Ac_2O. Cleavage of IX with alkylamines gave the corresponding amines (XI and XII). IX was converted into imidazolones (XIII) by heating with alkylamines in benzene. Ammonolysis of IX with NH_3 gave N-acetylglycinamide (XIV), which cyclized to imidazolone (XV) in the presence of NaOEt.
- 公益社団法人日本薬学会の論文
- 1975-01-25
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