Studies on the Centrally Acting Muscle Relaxants : The Spinal Reflex and the Spinal Gamma-Aminobutyric Acid Level in Young Chickens
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概要
- 論文の詳細を見る
As a part of the research on the mechanisms of action of the centrally acting muscle relaxants, the tentative correlation between the effect on the polysynaptic reflex and gamma-aminobutyric acid (GABA) level in the spinal cord was studied in young chicks. The spinal GABA concentration of chicks was found to be 12.1 mg/100 g wet tissue. The spinal GABA level was not significantly altered by several relaxants and stimulants. It was found that amino-oxyacetic acid (AOAA), an inhibitor of GABA transaminase, markedly increased the spinal GABA level in chicks. The inhibitory effect of mephenesin or exogenous GABA on the crossed extensor reflex in AOAA-pretreated chicks was not significantly different from that in AOAA-untreated ones. Consequently, evidence for the direct correlation between the action of the centrally acting muscle relaxant and the GABA level in the spinal cord could not be obtained.
- 公益社団法人日本薬学会の論文
- 1970-03-25
著者
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渡辺 和夫
Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
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福田 英臣
College Of Pharmacy Nihon University
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福田 英臣
Faculty Of Pharmaceutical Sciences Nagoya City University
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渡辺 和夫
Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address)faculty Of Pharmaceutical
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大島 隆
Faculty Of Pharmaceutical Sciences Nagoya City University
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工藤 佳久
Faculty of Pharmaceutical Sciences, Nagoya City University
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佐藤 志津子
Faculty of Pharmaceutical Sciences, Nagoya City University
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工藤 佳久
名古屋市立大学薬学部
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工藤 佳久
Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address) Laboratory Of Pharmacolo
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佐藤 志津子
Faculty Of Pharmaceutical Sciences Nagoya City University
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渡辺 和夫
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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