ヒヨコの多シナプス反射におよぼす中枢性筋弛緩薬ならびに数種薬物の作用

概要

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Crossed extensor reflexes of the leg were elicited by stimulation of the contralateral n. fibularis in the anesthetized and in the spinal chickens. Dose-response curves of several central muscle relaxants and of some central nervous system stimulants were obtained. Mephenesin and meprobamate depressed the reflex in the non-spinal chicks in the same degree as in the spinal ones, suggesting that the spinal cord was the main site of action of these drugs. Diazepam, chlordiazepoxide and carisoprodol depressed the reflex stronger in the non-spinal chicks than in the spinal chicks, probably because these drugs affected the brain as well as the spinal cord. Strychnine and picrotoxin showed characteristic stimulating effects. The antagonistic pattern of the relaxants against strychnine was different from that against picrotoxin. From these results it was confirmed that the crossed extensor reflex in the young chicks could be available for the investigation of the central muscle relaxants.
公益社団法人日本薬学会の論文
1968-10-25