Studies on the Drugs for Peptic Ulcer. Pharmacological Studies on the Effects of Synthetic Antispasmodics mixed with Antacid.
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概要
- 論文の詳細を見る
The stability of some antispasmodics mixed with antacid was examined, and the effect of combined administration of these two drugs was studied by experimental peptic ulcer. The antispasmodics used seemed not to be decomposed when they were mixed with synthetic aluminum silicate. From the resuls of the assay with mydriasis of mice eyes, is was shown that the antispasmodics by the antacid reduced the abesorption of these drugs from gastroin-tetinal tract, but practically this will not affect their pharmacological activity seriously, because gastric juice will facilitate the dissociation of the drug from antacid. To examine the effects of the drugs on peptic ulcer, Shay rats were used. Ulcer formation on Shay rat's stomach was treated as the duantal response, and ED 50 of some drugs was calculated. By this method it was shown that synergism of antispasmodics with antacid was of the type of potentiation.
- 公益社団法人日本薬学会の論文
- 1963-10-25
著者
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渡辺 和夫
Department of Medicinal Materials
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粕谷 豊
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University
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渡辺 和夫
Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
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粕谷 豊
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hoshi University
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高木 敬次郎
Department Of Pharmacotherapeutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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高木 敬次郎
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present
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渡辺 和夫
Faculty Of Pharmaceutical Sciences Nagoya City University:(present Address)faculty Of Pharmaceutical
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粕谷 豊
東京大学薬学部
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渡辺 和夫
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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渡辺 和夫
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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高木 敬次郎
Department of chemical Pharmacdogy, Faculty of Pharmaceutical Sciences, University of Tokyo
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