Chemicopharmacological Studies on Antispasmodic Action. XV. Non-specific Antispasmodic Action on Tracheal Muscle.

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(1) Tracheal strip preparation was proved to respond very sensitively to acetylcholine (ACh) and histamine. It is more suitable to test drug action on tracheal smooth muscle than tracheal chain. (2) From the present experimental results and on applying Ferguson's rule, the papaverine-like antispasmodic action, which is tested ordinarily against barium contraction of ileum, must be divided into two categories ; (a) the nonspecific inhibitory action, which is exerted by some physicochemical property of non-ionized molecules and can be tested on tracheal muscle, and (b) the specific unsurmountable inhibitory action, which is exhibited by ionized molecules of strong bases and can be tested on ileum. (3) Neutral esters such as isoamyl esters and weak bases such as papaverine exist as non-ionized molecules in physiological pH, and they have only nonspecific inhibitory action on any smooth muscles. Strong bases such as tertiary amines are ionized as much as 90% of the total amount in physiological solution. They exert specific but unsurmountable inhibitory action on ileum by their cation and exhibit non-specific action on tracheal muscle through their neutral base.
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1958-12-15