中枢興奮薬の脳室内投与と動物の行動

概要

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Intraventricular inflection into the conscious mouse was used to study the effects of some CNS stimulants. The effects observed were in good agreement with those observed in cats and dogs. Cocaine produced a rapid respiration, increased locomotor activity, exophthalmos and clonic convulsions. After pipradrol administration increased locomotor activity similar to that of methamphetamine, a fixed posture and clonic convulsion were observed. Morphine increased locomotor activity and produced mydriasis, Straub's reaction, hypersensitivity to sound and touch, respiratory depression and clonic convulsion. Analgesic effect was observed in dose not less than 1 μg. Theophylline caused a rapid respiration, Straub's reaction, mydriasis and lacrimation, and increased locomotor activity. Three antidepressant drugs, iproniazid, pheniprazine and tranylcypromine, produced certain common effects. With low doses short-lasting excitation appeared, but depression was observed with large doses. Imipramine caused mydriasis, Straub's reaction, increased sensitivity to sound and touch, and depression. Effective doses in subcutaneous administration were 10 to several hundreds times larger than those given intraventricularly as shown in Table I.
公益社団法人日本薬学会の論文
1968-07-25