Chemicopharmacological Studies on Antispasmodic Action. IX. Precise Discrimination of Atropine-like Activity and Papaverine-like Activity as Competitive and Non-competitive Antagonism to Acetylcholine.

概要

論文の詳細を見る
(1) ACh dose-response curve in the presence of various concentrations of antagonist was traced fully and it was suggested experimentaly that the curve moved parallel by the atropine-like action and its maximum response was depressed noncompetitively by the papaverine-like action. (2) It was made possible to discriminate precisely the atropine-like action as competitive antagonism to a low concentration of ACh 4×10^<-8>g./cc. and the papaverinelike action as non-competitive antagonism to a high concentration of ACh (1.11×10^<-4>g./cc.). (3) The potency ratios in relaxing the contraction due to the high concentration of ACh was almost the same as the ratios against BaCl_2.
公益社団法人日本薬学会の論文
1957-12-20