柴胡の薬理学的研究(第2報) : Crude Saikosidesの抗炎症その他の薬理作用

概要

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Crude saikosides are crude saponin fraction extracted from Bupleurum falcatum L. Anti-inflammatory and other pharmacological actions of this fraction are described. Crude saikosides showed a potent local irritation by topical application, but a significant decrease in dextran-induced edema of the rat paw, and increased capillary permeability in the mouse peritoneal cavity and in croton-induced granuloma pouch of the rat by the oral route. On the contrary, it did not show any inhibiting effect on carrageenin-induced edema, acetic acid-induced edema, adjuvant arthritis, and experimental liver fibrosis of the rat. In addition, it had no protective effect on histamine shock of the guinea pig and anaphylactic shock of the mouse. Crude saikosides did not affect gastric motility, but it was significantly effective in the prevention of the stress ulcer of the rat. Crude saikosides showed a strong stimulating effect in the intestinal propulsion test of the mouse. It markedly potentiated the contraction of isolated guinea pig ileum induced by acetylcholine, but not by histamine. Furthermore, crude saikosides showed a transient hypotensive action and a decrease of heart rate in the dog.
公益社団法人日本薬学会の論文
1969-10-25