実験潰瘍の治癒に関する研究(第1報) —酢酸潰瘍の治癒にともなう胃組織構成成分の変化—

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An Acetic Acid Ulcer was produced by injection of 0.05ml into the stomach walls of rats using Takagis method. This ulcer has been so-called “Intractable Ulcer” by Takagi et al. The rats were sacrificed, on days 5, 10, 20, 40 and 80 after injection of 10% acetic acid solution. The mucosa of the stomach was separated from the stroma, which contained submucosa, muscule and serosa, for determination of hexosamine or hydroxyproline content. General patterns of response were as follows ; On sides of the ulcer, there was always a group of glands containing newly formed PAS and alcian blue positive mucus. An early rise in hexosamine content, found as a peak on day 10, was followed by a decline in a later sample. These results suggest the importance of increased mucus content at the crater of the Acetic Acid Ulcer in the early stages of healing. In addition, significance of these results in the proliferation of collagen and mucus behavior in the healing process has been discussed.
社団法人日本薬理学会の論文