クマザサの薬理学的研究(第4報)クマザサ抽出分画(FIII)の急性毒性および薬理作用

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F I (precipitate), F II (sugar fraction, mol. wt.>10000) and F III (sugar fraction, mol. wt. 5000-10000) were obtained by further purification of a water-soluble fraction (crude Folin) extracted from Sasa albomarginata MAKINO et SHIBATA (Bambusaceae). Acute toxicity and pharmacological effects were examined mainly with F III in small animals. F III showed no apparent toxic effect in mice. It effected a significant decrease of rat dextran edema by topical administration. However, oral administration effected a decrease in the early and an increase in the later stage of rat dextran edema. Antagonistic effect was also observed against contraction induced by serotonin and nicotine in the isolated guinea-pig ileum. The therapeutic effect on rat stress ulcer was in the potency order of F III>F II>F I. F II and F III had no antibacterial effect. No remarkable effects were observed in surface anesthesia of guinea-pig carrageenin edema and urinary excretion of rats treated with F III. Furthermore, F II showed a slight antitumor effect against S180A in mice.
公益社団法人日本薬学会の論文
1979-06-25