Michael Reactions of 4-Acylmethylene-1,3 (2H, 4H)-isoquinolinediones with Malononitrile
スポンサーリンク
概要
- 論文の詳細を見る
2-Methyl-1,3 (2H, 4H)-isoquinolinedione (I) reacted with methylglyoxal to form 1,1-bis (2-methyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-4-yl) acetone (IV) in 58% yield. The Michael reaction of 2-methyl-4-phenacylidene-1,3 (2H, 4H)-isoquinolinedione (II) with malononitrile gave 1H-pyrano [2,3-c] isoquinoline (VI) and furo [2', 3' : 2,3] furo [5,4-c] isoquinoline (VII) derivatives in a ratio of 2 : 3. In the reaction of IV with malononitrile, retrograde Michael reaction occurred and resulted in the formation of 1,1H-pyrano [2,3-c] isoquinoline (IX) and 4-3'-furyl-1,3 (2H, 4H)-isoquinolinedione (X) derivatives. X-Ray structure analyses of VII and IX were performed.
- 社団法人日本薬学会の論文
- 1985-07-25
著者
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河合 賢一
Faculty of Pharmaceutical Sciences, University of Tokyo
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乙益 寛隆
Hoshi College of Pharmacy
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河合 賢一
Faculty Of Pharmaceutical Sciences Hoshi University
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乙益 寛隆
Faculty of Pharmaceutical Sciences, Hoshi University
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藤巻 照久
Faculty of Pharmaceutical Sciences, Hoshi University
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長瀬 弘昌
Faculty of Pharmaceutical Sciences, Hoshi University
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山口 良二
Faculty of Pharmaceutical Sciences, Hoshi University
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長瀬 弘昌
Faculty Of Pharmaceutical Sciences:hoshi University
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山口 良二
星薬科大学
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藤巻 照久
Faculty Of Pharmaceutical Sciences Hoshi University
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乙益 寛隆
Faculty Of Pharmaceutical Sciences Hoshi University
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