Reaction of 6-Nitroquinoxalines with Potassium Cyanide

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概要

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• 2,3-Disubstituted 6-nitroquinoxalines were reacted with potassium cyanide in alcoholic solutions to form 2,3-disubstituted 6-alkoxyquinoxaline-5-carbonitriles (I, III and IV) and 2,3-disubstituted-5-aminoisoxazolo [4,3-f] quinoxalines (II and V) at the yield of about 50 and 30%, respectively. The reaction of 2,4-dinitroaniline with potassium cyanide in methanolic solution gave o-methoxybenzonitrile compounds (VII and VIII). The same reaction was carried out in the presence of potassium ferricyanide and only dinitro-benzonitrile (VI) was obtained. Each VI and VII were reduced catalytically to o-phenyl-enediamine compounds and then condensed with benzil to yield the corresponding quinoxaline compounds. These were identical with the direct alkoxycyanation products of 2,3-disubstituted 6-nitroquinoxaline.

• 公益社団法人日本薬学会の論文
• 1970-01-25

著者

• 高橋 浩

  Faculty Of Pharmaceutical Science Hoshi University

• 乙益 寛隆

  Hoshi College of Pharmacy

• 高橋 浩

  Hoshi Institute of Pharmaceutical Sciences

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