Enantioselective Carbon-Carbon Bond Formation by Chiral Organotitanium Compounds ; Methyltitanium (S)-N-Acylpyrrolidinylmethoxide Diisopropoxides(Organic,Chemical)
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概要
- 論文の詳細を見る
New chiral compounds, (S)-N-acylpyrrolidinylmethanols (1b-f and Ih), were synthesized and chiral methyltitanium diisopropoxides (2a-h) were prepared from 1a-h. Enantioselective carbon-carbon bond formation between aromatic carbaldehydes and 2a-h was achieved in yields of 90-97% and 10.5-54.1%ee. The chiral auxiliaries (1a-h) were recovered in almost quantitative yields without any loss of optical purity.
- 社団法人日本薬学会の論文
- 1987-04-25
著者
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高橋 浩
Faculty Of Pharmaceutical Science Hoshi University
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高橋 浩
Institute of Medicinal Chemistry, Hoshi University
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東山 公男
Institute of Medicinal Chemistry, Hoshi University
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川端 章央
Institute of Medicinal Chemistry, Hoshi University
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東山 公男
星薬科大学
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川端 章央
Institute Of Medicinal Chemistry Hoshi University
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東山 公男
Faculty Of Pharmaceutical Science Hoshi University
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