Stereoselective Reaction of Chiral Mannich Bases. 1,5-Asymmetric Inductions of (S)-3-4'-Isopropyl-1', 3'-oxazolidino-1-arylpropan-1-ones
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概要
- 論文の詳細を見る
Chiral Mannich bases, (S)-3-oxazolidino-1-arylpropan-1-ones (3a, 3b), were obtained from acetophenone, (S)-valinol, and paraformaldehyde. The reaction of these 1-arylpropan-1-ones with organometallic reagents gave 3-oxazolidino- and 3-hydroxyethylamino-1-arylpropan-1-ols (5a, 5b, 6a-f) in good yields. These 1-arylpropan-1-ols consisted of two diastereomers and the ratios of major to minor products were estimated by proton nuclear magnetic resonance spectroscopy. The 1,5-asymmetric induction of the chiral Mannich bases showed low stereoselectivity.
- 社団法人日本薬学会の論文
- 1984-11-25
著者
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高橋 浩
Faculty Of Pharmaceutical Science Hoshi University
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高橋 浩
Institute of Medicinal Chemistry, Hoshi University
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東山 公男
Institute of Medicinal Chemistry, Hoshi University
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棚橋 浩治
Institute of Medicinal Chemistry, Hoshi University
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東山 公男
星薬科大学
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棚橋 浩治
Institute Of Medicinal Chemistry Hoshi University
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東山 公男
Faculty Of Pharmaceutical Science Hoshi University
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