縮合Quinoxaline化合物の合成研究(第3報) : 1,2-Dihydroimidazo[1,2-α]-quinoxalineおよび1,2-Dihydro-3H-pyrimido[1,2-α]quinoxaline化合物

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概要

• 論文の詳細を見る

• 2-Chloroquinoxalines (Ia-Ic) were reacted with ethanolamine to give 2-(2-hydroxyethylamino)-quinoxalines (IIa-IIc). Similar reactions with γ-hydroxypropylamine in place of ethanolamine were carried out to give 2-(3-hydroxypropylamino)-quinoxalines (IIIa-IIIc). When IIa-IIc and IIIa-IIIc were each refluxed in phosphorus oxychloride, 1,2-dihydroimidazo [1,2-α] quinoxalines (IVa-IVc) and 1,2-dihydro-3H-pyrimido [1,2-α]-quinoxalines (Va-Vc) were respectively produced. IVa-IVc and Va-Vc were stable in acid solution but unstable in alkali solution. Ring fission occurred easily in the latter case, and IVb and Vc were converted into VIa and VIb, respectively. IVb was also obtained by replacement of the chloro group in Ib with aziridine. VIII and IX were synthesized in relation to 1,2-dihydroimidazo [1,2-α] quinoxalines.

• 公益社団法人日本薬学会の論文
• 1970-11-25

著者

• 高橋 浩

  Faculty Of Pharmaceutical Science Hoshi University

• 高橋 浩

  星薬科大学

• 吉田 桂

  Faculty of Pharmaceutical Sciences, Hoshi University

• 乙益 寛隆

  星薬科大学

• 吉田 桂

  星薬科大学

• 吉田 桂

  Faculty Of Pharmaceutical Sciences Hoshi University

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