The Remarkable Effect of Titanium Tetraisopropoxide in Diastereoselective Reaction of Carbaldehydes with Chiral Benzenesulfonamide Lithium Complexes
スポンサーリンク
概要
- 論文の詳細を見る
Chiral benzenesulfonamide titanium ate-complexes (4 and 8) were prepared from the lithium complexes (2 and 6) by treatment with titanium tetraisopropoxide. The diastereoselective reactions of aromatic carbaldehydes with 4 and 8 were performed, and the chiral o-(1-aryl-1-hydroxymethyl)benzenesulfonamides (3a-d and 7a-e) were obtained in 80-87% yields. The diastereomeric excesses (d.e.) of these products were evaluated as 62-82%. These compounds were also prepared from the lithium complexes (2 and 6), but the d.e. values were only 6-14% in this case.
- 社団法人日本薬学会の論文
- 1991-02-25
著者
-
高橋 浩
Faculty Of Pharmaceutical Science Hoshi University
-
東山 公男
Faculty of Pharmaceutical Sciences, Hoshi University
-
津吹 猛
Faculty of Pharmaceutical Science, Hoshi University
-
東山 公男
星薬科大学
-
東山 公男
Faculty Of Pharmaceutical Science Hoshi University
-
津吹 猛
Faculty Of Pharmaceutical Science Hoshi University
関連論文
- The Glycosides of Martynia louisiana MILL. A New Phenylpropanoid Glycoside, Martynoside
- ABSOLUTE STRUCTURE OF (+)-13β-HYDROXYMAMANITE, A POSSIBLE METABOLINE OF (-)-BAPTIFOLINE
- Michael Reactions of 3-Acylmethyleneoxindoles with Active Methylene Compounds
- Stereoselective Reduction of (S)-4-Isopropyl-3-phenacyl-1,3-oxazolidin-2-one by Means of 1,4-Asymmetric Induction : Synthesis of Chiral 2-Amino-1-phenylethanols
- Synthesis and Absolute Configuration of Optically Pure (S)- and (R)-Diarylmethylamines
- 薬剤師ボランティアをどう薬学教育に生かすか : 阪神・淡路大震災の経験から
- Diastereoselective Addition of Chiral Aliphatic Imines and 2-Alkyl-1,3-oxazolidines to Organometallic Reagents
- 医療薬学と有機化学の接点
- 薬務行政担当者からみた薬学教育 : 矢野朝水・厚生省薬務局企画課長に聞く
- AFMC(アジア医薬化学連合)をめぐる話題 : 古賀直文先生に聞く
- Highly Diastereoselective Reaction of Chiral o-[2-(1,3-Oxazolidinyl)]benzaldehydes with Alkylmetallic Reagents : Synthesis of Chiral 3-Substituted Phthalides
- Organometallic Reactions Characteristic of Chiral Heterocyclic Compounds : Synthesis and Stereoselective Grignard Reaction of Chiral 4-Oxa, -7,7a-diazaperhydroindans
- The Remarkable Effect of Titanium Tetraisopropoxide in Diastereoselective Reaction of Carbaldehydes with Chiral Benzenesulfonamide Lithium Complexes
- Highly Diastereoselective Reaction of (3aS, 6R)-5-Oxa-7,8a-diazaperhydroazulen-8-ones with Diethylzinc
- The Absolute Configuration and Stereoselective Grignard Reaction of N-Substituted 4-Phenyl-1,3-oxazolidines
- Diastereoselective 1,6-Asymmetric Induction to Obtain Chiral 4-Hydroxyethylaminobutanones by Using Methyltitanium Triisopropoxide
- Enantioselective Reaction of Aldehydes with Chiral Alkyltitanium Ate-Complexes
- Enantioselective Carbon-Carbon Bond Formation by Chiral Organotitanium Compounds ; Methyltitanium (S)-N-Acylpyrrolidinylmethoxide Diisopropoxides(Organic,Chemical)
- Asymmetric α-Substituted Phenethylamines. VI. : Synthesis and Analgesic Activity of Optically Pure (R)- and (S)-N-Akyl-1-cyclohexyl-2-phenylethylamines
- Highly Diastereoselective 1,5-Asymmetric Induction to 3-Oxazolidino-1-phenylpropan-1-ones by Using Organotitanium Triisopropoxides
- Asymmetric α-Substituted Phenethylamines. V. Synthesis of Chiral 1-Alkyl-2-phenylethylamines via Grignard Reaction of 4-Phenyl-1,3-oxazolidines
- Stereoselective Reaction of Chiral Mannich Bases. 1,5-Asymmetric Inductions of (S)-3-4'-Isopropyl-1', 3'-oxazolidino-1-arylpropan-1-ones
- Asymmetric α-Substituted Phenethylamines. IV. The Synthesis and Analgesic Activity of Optically Pure (S) and (R)-1-Cyclohexyl-and 1-Cyclohexenyl-2-phenylethylamines
- Alkylation of a Chiral Hydrazone by Means of Asymmetric Addition of Grignard Reagents to the Carbon-Nitrogen Double Bond
- Asymmetric Reaction of Chiral Azomethines with Organometallic Reagents
- Formylation of Phenols with Electron-withdrawing Groups in Strong Acids. Synthesis of Substituted Salicylaldehydes
- Asymmetric α-Substituted Phenethylamines. III. The Synthesis and Analgesic Activity of optically Pure (S)- and (R)-1-Aryl-2-phenylethylamines
- Asymmetric α-Substituted Phenethylamines. II. The Enantioselective Synthesis of 1-Aryl-2-phenylethylamines from L- and D-Amino Acids by Means of 1,3-Asymmetric Induction
- Asymmetric α-Substituted Phenethylamines. I. Synthesis of Optically Pure 1-Aryl-N-(2'-hydroxy-1'-isopropylethyl)-2-phenylethylamines
- l-エフェドリンのキラリティーを利用した合成 : アラニンおよびフェニルグリシンの不斉合成
- Studies on the Syntheses of Heterocyclic Compounds and Natural Products. MXVI. Aziridine in Alkaloid Synthesis. (6). Alternative Synthesis of Isopavine-Type Alkaloid, (±)-Reframidine
- Cationic Cholesterol Derivatives for Gene Delivery into the Lung
- Synthesis of 4-Hydroxymethylene-1,3(2H, 4H)-iso-quinolinediones and Related Compounds
- Spiro Heterocyclic Compounds. IV. Synthesis of Spiro [oxindole-3,4'-(2', 3'-dihydro-4'H-pyran)] and Spiro [oxindole-3,4'-(1', 4'-dihydropyridine)] Compounds
- Spiro Heterocyclic Compounds. III. Synthesis of Spiro[oxindole-3,4'-(4'H-pyran)]Compounds
- (-)-及び(+)-ストリキニーネの全合成
- カシワバハグマの苦味成分 : Glucozaluzanin C
- ジルチアゼムの皮膚透過に及ぼすメントールおよび O-エチルメントールの効果
- オキシブチニンの皮膚透過におけるメントール誘導体の影響
- 6-Acyldecahydro[1,6]naphthyridineのマウスにおける抗侵害作用
- Asymmetric Synthesis by Using the Chirality of l-Ephedrine. III. Reaction of N-(Arylmethylideneamino) ephedrine with Benzylmagnesium Chloride and Phenyllithium
- N-Alkylaminoephedrine類の合成と気管支平滑筋に対する影響
- 徹底的に「もの」の側から(薬品化学で何を教えるか)
- きーワードについて感じたこと
- (+)-erythro-2-Methylamino-1,2-diphenylethanolの絶対配位およびそのキラリティーを利用した不斉合成
- Unconjugated Chiral Azomethines : Structure of N-Isobutylidene Derivatives of (S)-α-Amino Acid Esters
- Spiro Heterocyclic Compounds. I. Synthesis of Spiro-[imidazolidine-4,3'-INDOLINE]-2,2', 5-triones
- Synthesis of Nitrophenylpiperidine N-Oxides and Their Reductive Intramolecular Ring-Closure
- Synthesis and Conformation of 4,5-Disubstituted 5,6-Dihydro-4H-imidazo[1,5,4-d, e]quinoxalines
- A New Synthesis of 5,6-Dihydro-4H-imidazo[1,5,4-d, e]quinoxaline-5-ones
- 縮合Quinoxaline化合物の合成研究(第3報) : 1,2-Dihydroimidazo[1,2-α]-quinoxalineおよび1,2-Dihydro-3H-pyrimido[1,2-α]quinoxaline化合物
- Synthesis of Condensed Quinoxalines. II. A New Synthesis of Pyrrolo- [2,3-b] quinoxalines
- Reaction of 6-Nitroquinoxalines with Potassium Cyanide
- Reaction of Aromatic Heterocyclic Nitro Compounds with Potassium Cyanide. III. Some Nitroquinoline 1-Oxides
- Reaction of Aromatic Heterocyclic Nitro Compound with Potassium Cyanide. I. 3-Nitroquinoline
- Studies on the Structures of Diazine N-Oxides. II. Dipole Moments of Some Alkoxy-derivatives of Pyrimidine, Pyridazine and their N-Oxides.