Asymmetric α-Substituted Phenethylamines. I. Synthesis of Optically Pure 1-Aryl-N-(2'-hydroxy-1'-isopropylethyl)-2-phenylethylamines
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概要
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Optically pure 1-aryl-N-(2'-hydroxy-1'-isopropylethyl)-2-phenylethylamines (3a-c) were synthesized by the reactions of N-(2-hydroxy-1-isopropylethyl) arylmethylideneamines (2a-c) with benzylmagnesium chloride. The diastereomers (5a-c) were prepared from N-(2-hydroxy-1-isopropylethyl) phenylethylideneamine (4) and aryllithium compounds. The optical purity of 3a was elucidated and the absolute configuration was determined by synthesis via an alternative route. The characteristic methyl signals in the nuclear magnetic resonance (NMR) spectra suggested the configurations of the chiral amines (3a-c and 5a-c).
- 社団法人日本薬学会の論文
- 1982-09-25
著者
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高橋 浩
Faculty Of Pharmaceutical Science Hoshi University
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鈴木 雄二
Kaken Pharmaceutical Co., Ltd.
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鈴木 雄二
Hoshi College Of Pharmacy
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高橋 浩
Hoshi Institute of Pharmaceutical Sciences
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稲垣 英和
Hoshi Institute of Pharmaceutical Sciences
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