Formylation of Phenols with Electron-withdrawing Groups in Strong Acids. Synthesis of Substituted Salicylaldehydes
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概要
- 論文の詳細を見る
Salicylaldehydes with electron-withdrawing groups, i.e., 2-hydroxy-5-nitrobenzaldehyde (2a), methyl 3-formyl-4-hydroxybenzoate (2b), methyl 5-chloro-3-formyl-2-hydroxybenzoate (2c), 3,5-dichloro-2-hydroxybenzaldehyde (2d), 5-cyano-2-hydroxybenzaldehyde (2e), and 5-fluoro-2-hydroxybenzaldehyde (2f), were synthesized by the formylation of the corresponding phenols (1a-f) with hexamethylenetetramine in 75% polyphosphoric acid, methanesulfonic acid, or trifluoroacetic acid. The yields of these reactions were better than those of the Duff reaction.
- 社団法人日本薬学会の論文
- 1983-05-25
著者
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高橋 浩
Faculty Of Pharmaceutical Science Hoshi University
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鈴木 雄二
Kaken Pharmaceutical Co., Ltd.
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鈴木 雄二
Hoshi College Of Pharmacy
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