Asymmetric α-Substituted Phenethylamines. IV. The Synthesis and Analgesic Activity of Optically Pure (S) and (R)-1-Cyclohexyl-and 1-Cyclohexenyl-2-phenylethylamines

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概要

• 論文の詳細を見る

• New optically pure (1S, 1'S)-and (1R, 1'R)-1-cycloalkyl-N-2'-hydroxy-1'-isopropylethyl-2-phenylethylamine hydrochlorides (3a-j) were synthesized in good yields. The analgesic activities of these hydrochlorides were evaluated by the acetic acid writhing method and the bradykinin-induced flexor reflex method. The structure of 3f'・HCl was elucidated by X-ray analysis. The relationship between the analgesic activity and the conformation of the 1-2 bond of these amines is discussed.

• 社団法人日本薬学会の論文
• 1984-07-25

著者

• 高橋 浩

  Faculty Of Pharmaceutical Science Hoshi University

• 高橋 浩

  Institute of Medicinal Chemistry, Hoshi University

• 千田 康裕

  Institute of Medicinal Chemistry, Hoshi University

• 鈴木 勉

  Institute of Medicinal Chemistry, Hoshi University

• 柳浦 才三

  Institute of Medicinal Chemistry, Hoshi University

• 大西 啓

  Institute of Medicinal Chemistry, Hoshi University

• 大西 啓

  Institute Of Medicinal Chemistry Hoshi University

• 千田 康裕

  Institute Of Medicinal Chemistry Hoshi University

• 柳浦 才三

  星薬料大学・薬理学教室

• 柳浦 才三

  Department Of Pharmacology Hoshi College Of Pharmacy

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