Asymmetric Reaction of Chiral Azomethines with Organometallic Reagents

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概要

• 論文の詳細を見る

• Reaction of (E)-(S)-N-(1-isopropyl-2-methoxyethyl)benzylideneamine (2) with ethylmagnesium bromide gave a mixture of (1S, 1'S)- and (1R, 1'S)-N-(1'-isopropyl-2'-methoxyethyl)-1-phenylpropylamines (3) (91 : 9%). (E)-(S)-N-(1-Isopropyl-2-methoxyethyl)propylideneamine (5) was treated with phenyllithium to give (1R, 1'S)- and (1S, 1'S)-3 (95 : 5%). On the other hand, reaction of (E)-(S)-N-(2-hydroxy-1-isopropylethyl)benzylideneamine (6) with ethylmagnesium bromide yielded a mixture of (1S, 1'S)- and (1R, 1'S)-N-(2'-hydroxy-1'-isopropylethyl)-1-phenylpropylamines (7) (78 : 22%). The absolute configurations of these amines were determined by circular dichroism (CD) spectroscopy and comparison with authentic samples synthesized by alternative methods.

• 社団法人日本薬学会の論文
• 1983-08-25

著者

• 高橋 浩

  Faculty Of Pharmaceutical Science Hoshi University

• 鈴木 雄二

  Hoshi College Of Pharmacy

• 鈴木 雄二

  Faculty of Pharmaceutical Sciences, Hoshi University

• 高橋 浩

  Kaken Pharmaceutical Co., Ltd.

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