Organometallic Reactions Characteristic of Chiral Heterocyclic Compounds : Synthesis and Stereoselective Grignard Reaction of Chiral 4-Oxa, -7,7a-diazaperhydroindans
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概要
- 論文の詳細を見る
New heterocyclic compounds, 6-phenyl-4-oxa-7,7a-diazaperhydroindans (5 and 6), were synthesized by condensation of chiral 2-hydroxyethylhydrazines prepared from (R)-phenylglycinol with γ-chlorobutyraldehyde. The stereoselective Grignard reaction of 5 and 6 proceeded to give chiral 2-substituted 1-[N-(2-hydroxy-1-phenylethyl)amino] pyrrolidines(7a-d and 8a-d). The structures of these products were determined by comparison with authentic samples, and the reaction mechanism is proposed to involve an intermediate iminium salt.
- 社団法人日本薬学会の論文
- 1991-04-25
著者
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高橋 浩
Faculty Of Pharmaceutical Science Hoshi University
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東山 公男
Faculty of Pharmaceutical Sciences, Hoshi University
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仙田 隆史
Faculty of Pharmaceutical Science, Hoshi University
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東山 公男
星薬科大学
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東山 公男
Faculty Of Pharmaceutical Science Hoshi University
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仙田 隆史
Faculty Of Pharmaceutical Science Hoshi University
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