Michael Reactions of 3-Acylmethyleneoxindoles with Active Methylene Compounds

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概要

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• 3-Acylmethyleneoxindoles (Ia-d) reacted with active methylene compounds (IIa-d) in EtOH, in the presence of NaOC_2H_5 as a catalyst at room temperature, to afford the corresponding normal Michael adducts (IIIa-f). The reactions of Ia with IIa, Ic with IIa and Id with IIa in EtOH under reflux, in the presence of Et_2NH as a catalyst, produced the corresponding 2', 4'-substituted 3-(5'-amino-2'H-furan-3'-ylidene) oxindoles (IVa-c), while the reactions of Ib with IIa, Ib with IIb and Ic with IIb afforded the 2', 4'-substituted 3-(5'-amino-3'-furyl) oxindole compounds (Va-c), respectively. The Michael adducts (IIIa-c), on being refluxed in EtOH with base catalyst, gave IVa, Vb and IVb, respectively, in high yields, whereas IIId-f did not change at all. X-Ray crystallographic analyses of IVb and Vb were performed.

• 社団法人日本薬学会の論文
• 1985-02-25

著者

• 河合 賢一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 乙益 寛隆

  Hoshi College of Pharmacy

• 河合 賢一

  Faculty Of Pharmaceutical Sciences Hoshi University

• 東山 公男

  Faculty of Pharmaceutical Sciences, Hoshi University

• 乙益 寛隆

  Faculty of Pharmaceutical Sciences, Hoshi University

• 長瀬 弘昌

  Faculty of Pharmaceutical Sciences, Hoshi University

• 山口 良二

  Faculty of Pharmaceutical Sciences, Hoshi University

• 長瀬 弘昌

  Faculty Of Pharmaceutical Sciences:hoshi University

• 山口 良二

  星薬科大学

• 乙益 寛隆

  Faculty Of Pharmaceutical Sciences Hoshi University

• 東山 公男

  星薬科大学医薬品化学研究室

• 東山 公男

  Faculty Of Pharmaceutical Science Hoshi University

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