Studies on Fungal Products. XVIII. : Isolation and Structures of a New Fungal Depsidone Related to Nidulin and a New Phthalide from Emericella unguis
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概要
- 論文の詳細を見る
Two new compounds, 2-chlorounguinol (1), C_<19>H_<17>ClO_5,and 3-ethyl-5,7-dihydroxy-3,6-dimethylphthalide (5), C_<12>H_<14>O_4,were isolated from the dichloromethane extract of culture filtrate of Emericella unguis (anamorph : Aspergillus unguis), together with nidulin (2) and unguinol (4). The structure of 2-chlorounguinol (1) was determined on the basis of spectroscopic investigations and X-ray crystallography, and that of the phthalide (5) was confirmed by spectroscopic investigations of several derivatives. 2-Chlorounguinol (1) is a fungal depsidone related to nidulin (2), originally isolated from E. nidulans. This is the first example of the isolation of a 3,3-disubstituted phthalide as a naturally occurring compound.
- 社団法人日本薬学会の論文
- 1988-06-25
著者
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河合 賢一
星薬大
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河合 賢一
Faculty of Pharmaceutical Sciences, University of Tokyo
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仲嶋 正一
Faculty of Pharmaceutical Sciences, Hoshi University
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河合 賢一
Faculty Of Pharmaceutical Sciences Hoshi University
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山崎 幹夫
Faculty of Pharmaceutical Sciences, Chiba University
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川原 信夫
Faculty of Pharmaceutical Sciences, Hoshi University
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佐藤 祐美子
Faculty of Pharmaceutical Sciences, Chiba University
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山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
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佐藤 祐美子
Faculty Of Pharmaceutical Sciences Chiba University
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Kawai Koji
Basic Research Laboratories Toray Industries Inc.
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仲嶋 正一
Faculty Of Pharmaceutical Sciences Hoshi University
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Kawahara N
National Institute Of Health Sciences
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Nakajima S
Shionogi Research Laboratories Shinogi & Co. Ltd.
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