84(PA3-4) Emericella属菌類の生産する新規インドロジテルペン誘導体Emindole類およびその関連化合物(ポスター発表の部)

概要

論文の詳細を見る
In the course of survey of paxilline (1) in Emericella spp., new-type indoloditerpenes, emindoles DA (2) and DB (3), and emindole SA (4), were isolated from the mycelial extract of E. desertorum and E. striata, respectively. The structures of 2, 3, and 4 were determined on the basis of the spectroscopic and chemical data of their derivatives and X-ray crystallography of emindole DA monoacetate (9). Three new compounds related to 1, emindole SB (6), dehydroxypaxilline (7), and paxilline acetate (8), were also isolated along with 1 and paspaline (5) from the mycelium of E. striata, and their structures were elucidated by the spectroscopic and chemical investigation. It is very interesting that two different types of indoloditerpenes, emindole SA (4) and paxilline analogs (1, 5, 6, 7 and 8) were isolated from the same fungus, E. striata, and that the diastereomers differently connecting with (3-indolyl)methyl group, emindoles DA (2) and SA (4), were isolated from two species belonging to Emericella spp. Isolation of 5, 6, 7, and 8 from the same fungus may suggest the biogenesis of paxilline (1).
天然有機化合物討論会の論文
1987-07-25