Pharmacologically Active Components of Todopon Puok (Fagraea racemosa), a Medicinal Plant from Borneo
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概要
- 論文の詳細を見る
The lignans of (+)-pinoresinol, (+)-epipinoresinol, (+)-lariciresinol and (+)-isolariciresinol together with phenols such as syringaldehyde and 7,8-dihydro-7-oxy-coniferyl alcohol were isolated from Todopon Puok (Fagraea racemosa JACK ex WALL.), a medicinal plant from Borneo, using a bioassay of the relaxation effect on norepinephrine (NE)-induced contraction in rat aortic strips. The plant extract also exhibited analgesic properties in the acetic acid-induced writhing and tail perssure tests in mice, with the activity being concentrated in the lignan fraction. (+)-Pinoresinol showed analgesic effect on writhing symptoms in mice which were dose-dependent, and produced local anesthesia in guinea pigs.
- 社団法人日本薬学会の論文
- 1995-12-15
著者
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奥山 恵美
Faculty of Pharmaceutical Sciences, Chiba University
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山崎 幹夫
Faculty of Pharmaceutical Sciences, Chiba University
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奥山 恵美
千葉大院薬
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山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
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鈴村 邦治
Faculty of Pharmaceutical Sciences, Chiba University
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奥山 恵美
千葉大学 院薬
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鈴村 邦治
Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn
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