Analgesic Components from Bornean Medicinal Plants, Tabernaemontana pauciflora BLUME and Tabernaemontana pandacaqui POIR
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概要
- 論文の詳細を見る
The analgesic components were isolated from a Bornean medicinal plant, Tabernaemontana pauciflora BLUME (syn. Ervatamia blumeana MARK gr.), and the major components were identified as coronaridine and 3-(2-oxo-propyl)coronaridine. Four minor components were estimated to be 5R- and 5S-(2-oxopropyl)coronaridine, 3-(2-oxopropyl)voacangine and 3,3'-(oxopropyl)dicoronaridine, which might be produced during the isolaion process. Voacangine was also isolated as a major component of T. pandacaqui POIR. Coronaridine and voacangine exhibited significant analgesic and hypothermic effects in mice at a dose of 25 mg/kg, p.o., while 3-(2-oxopropyl)coronaridine was less effective. The former two compounds also revealed a surface anesthesia.
- 社団法人日本薬学会の論文
- 1992-08-25
著者
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奥山 恵美
Faculty of Pharmaceutical Sciences, Chiba University
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山崎 幹夫
Faculty of Pharmaceutical Sciences, Chiba University
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奥山 恵美
千葉大院薬
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山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
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高 麗宏
Faculty of Pharmaceutical Sciences, Chiba University
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奥山 恵美
千葉大学 院薬
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高 麗宏
Faculty Of Pharmaceutical Sciences Chiba University
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