Wrightiamines A and B, Two New Cytotoxic Pregnane Alkaloids from Wrightia javanica

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概要

• 論文の詳細を見る

• Two new pregnane alkaloids, wrightiamines A (1) and B (2), were isolated from the extract of the tropical Apocynaceous plant Wrightia javanica collected in Thailand, and their structures were elucidated by spectral data. Wrightiamine B (2) was preparaed from 3β-hydroxy-5α-pregnan-20-one to establish the configuration of the C-20 position as S, Wrightiamine A (1) exhibited cytotoxic activity against vincristine-resistant murine leukemia P388 cells.

• 公益社団法人日本薬学会の論文
• 2003-06-01

著者

• Ishibashi Masami

  Graduate School of Pharmaceutical Sciences, Chiba University

• INAGAKI MASANORI

  Faculty of Pharmaceutical Sciences, Kyushu University

• 藤本 治宏

  千葉大院薬

• 奥山 恵美

  千葉大学 院薬

• KOYANO Takashi

  Temko Corporation

• HAYASHI Masahiko

  The Kitasato Institute

• KOMIYAMA Kanki

  The Kitasato Institute

• Komiyama K

  The Kitasato Inst.

• Komiyama Kanki

  The Kitasaro Institute And School Of Pharmaceutical Sciences The Kitasato University

• Komiyama Kanki

  北里研究所

• FUJIMOTO Haruhiro

  Graduate School of Pharmaceutical Sciences, Chiba University

• Hayashi M

  The Kitasato Institute

• Hayashi Masahiko

  The Kitasato Inst.

• 藤本 治宏

  Chiba Univ. Chiba Jpn

• KAWAMOTO Souichi

  Graduate School of Pharmaceutical Sciences, Chiba University

• KOWITHAYAKORN Thaworn

  Department of Horticulture, Faculty of Agriculture, Khon Kaen University

• OKUYAMA Emi

  Graduate School of Pharmaceutical Sciences, Chiba University

• Ishibashi Masami

  Graduate School Of Pharmaceutical Sciences Chiba Univ.

• Kowithayakorn Thaworn

  Faculty Of Agriculture Khon Kaen University

• Komiyama K

  The Kitasato Institute

• Kawamoto Souichi

  Graduate School Of Pharmaceutical Sciences Chiba University

• OKUYAMA Emi

  Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Josai International University

• Kamei K

  The Kitasato Institute

• Ito Masaki

  The First Department Of Internal Medicine Mie University School Of Medicine

• Okuyama E

  Laboratory Of Pharmacognosy Faculty Of Pharmaceutical Sciences Josai International University

• Kowithayakorn Thaworn

  Department Of Horticulture Faculty Of Agriculture Kohn Kaen University

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