Differences in the Formation and Fragmentation of Sodium Adduct Ions between Tertiarybutoxycarbonyl-Protected Prolyproline Diastereomers in Fast Atom Bombardment Mass Spectrometry

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概要

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• The effect of Na^+ ions on the fragmentation of tertiarybutoxycarbonyl (Boc) protected prolylproline (Pro-Pro) diastereomers, Boc-Pro-Pro and Boc-D-Pro-Pro, was studied in positive-ion fast atom bombardment (FAB) and tandem mass spectrometry. The formaiton of the [M+Na]^+ ion for Boc-D-Pro-Pro was more predominant than that for Boc-Pro-Pro on the addition of sodium chloride in positive-ion FAB mass spectrometry, suggesting that Boc-D-Pro-Pro has a stronger Na^+ ion affinity than Boc-Pro-Pro. In the collisional-activated decomposition mass spectra of the [M+Na]^+ ions, the abundance of the [M+Na-C(CH_3)_3+H]^+ ion, which is due to the loss of a tertiarybutyl group from the [M+Na]^+ ion for Boc-D-Pro-Pro, was higher than that for Bos-Pro-Pro. These results indicate that the interaction of the Na^+ ion with Boc-Pro-Pro is different from that with Boc-D-Pro-Pro in the FAB condition, and these diastereomers are distinguished by the addition of a Na^+ ion in FAB and tandem mass spectrometry.

• 公益社団法人日本薬学会の論文
• 1999-07-15

著者

• INAGAKI MASANORI

  Faculty of Pharmaceutical Sciences, Kyushu University

• HIGUCHI RYUICHI

  Faculty of Pharmaceutical Sciences, Kyushu University

• Ito Naofumi

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Isobe R

  Department Of Medical Electronics Engineering Faculty Of Engineering Towa University

• Isobe Ryuichi

  Tohwa University

• Yamamoto Megumi

  School Of Agriculture Kyushu Tokai University

• Higuchi Ryuichi

  Graduate School Of Pharmaceutical Sciences Kyushu Univ.

• Higuchi Ryuichi

  Faculty Of Pharmaceutical Sciences Kyushu University

• ISOBE Ryuichi

  Department of Medical Electronics Engineering, Faculty of Engineering, Towa University

• YAMAMOTO MAGOBEI

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Isobe Ryuichi

  Department Of Medical Electronics Engineering Faculty Of Engineering Towa University

• Isobe R

  Faculty Of Pharmaceutical Sciences Kyushu University

• TSUNEMATSU Hideaki

  Faculty of Pharmaceutical Sciences, Fukuoka University

• HANAZONO Hiroshi

  Faculty of Pharmaceutical Sciences, Fukuoka University

• SOEDA Yasuko

  Faculty of Pharmaceutical Sciences, Kyushu University

• Soeda Y

  Faculty Of Pharmaceutical Sciences Kyushu University

• Inagaki Masanori

  Faculty Of Pharmaceutical Sciences Kyushu University

• Ito Masaki

  The First Department Of Internal Medicine Mie University School Of Medicine

• Yamamoto Magobei

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Hanazono Hiroshi

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Tsunematsu H

  Faculty Of Pharmaceutical Sciences Fukuoka University

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