Isolation and Structure of Four New Ceramides from the Starfish Luidia maculata
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概要
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A new sphingosine-type ceramide LMCer-1-1 (1) and three new phytosphingosine-type ceramides, LMCer-2-1 (2), LMCer-2-6 (3), and LMCer-2-7 (4), were isolated from the anti-hyperglycemic active ceramide molecular species LMCer-1 and LMCer-2, obtained from the less polar fraction of the chloroform-methanol extract of the whole bodies of Luidia maculata. The structures of these ceramides were determined on the basis of chemical and spectroscopic evidence as: (2S, 3R, 4E, 2'R)-2-(2-hydroxyhexadecanoylamino)-16-methyl-4-octadecene-1, 3-diol (1), (2S, 3S, 4R, 2'R)-2-(2-hydroxyhexadecanoylamino)-16-methyl-octadecane-1, 3, 4-triol (2), (2S, 3S, 4R, 2'R)-2-(2-hydroxydocosanoylamino)-hexadecane-1, 3, 4-triol (3), and (2S, 3S, 4R, 2'R)-2-(2-hydroxydocosanoylamino)-14-methyl-hexadecane-1, 3, 4-triol (4).
- 2006-12-01
著者
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INAGAKI MASANORI
Faculty of Pharmaceutical Sciences, Kyushu University
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HIGUCHI RYUICHI
Faculty of Pharmaceutical Sciences, Kyushu University
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HIGUCHI Ryuichi
Graduate School of Pharmaceutical Sciences, Kyushu University
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Nakamura Katsuya
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nakamura K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Tanaka Miyuki
Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.
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YAMADA Muneo
Biochemical Research Laboratory, Morinaga Milk Industry
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Nakamura Kazufumi
Faculty Of Pharmaceutical Sciences Kyushu University
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INAGAKI Masanori
Graduate School of Pharmaceutical Sciences, Kyushu University
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Ikeda Yuriko
Graduate School Of Pharmaceutical Sciences Kyushu University:faculty Of Pharmaceutical Sciences Naga
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Higuchi Ryuichi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Higuchi Ryuichi
Faculty Of Pharmaceutical Sciences Kyushu University
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Nakamura Katsuji
Tsukuba Research Laboratories Eisai Co. Ltd.
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Yamada Muneo
Biochemical Research Laboratory Morinaga Milk Industry
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Nakamura K
Department Of Physiology Ii Iwate Medical University School Of Medicine
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IKEDA Yuriko
Faculty of Pharmaceutical Sciences, Kyushu University
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KAWATAKE Satoshi
Faculty of Pharmaceutical Sciences, Kyushu University
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MISAWA Eriko
Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd.
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Misawa Eriko
Biochemical Research Laboratory Morinaga Milk Industry Co. Ltd.
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Inagaki Masanori
Faculty Of Pharmaceutical Sciences Kyushu University
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Ito Masaki
The First Department Of Internal Medicine Mie University School Of Medicine
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Kawatake Satoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Inagaki M
Graduate School Of Pharmaceutical Sciences Chiba University
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