Neuritogenic Activity-Guided Isolation of a Free Base Form Manzamine A from a Marine Sponge, Acanthostrongylophora aff. ingens(Thiele, 1899)
スポンサーリンク
概要
- 論文の詳細を見る
Two manzamine-class alkaloids, manzamine A (1) and 8-hydroxymanzamine (2) were isolated from a Japanese marine sponge Acanthostrongylophora aff. ingens, together with three known alkaloids manzamine E (3), manzamine F (4), and manzamine X (5). The spectral features of 1 and 2 were different from the reported data. Detailed structure analysis using 2D NMR revealed the structure of 1 and 2 as a free base form of hydrochloric salt. These manzamine-class alkaloids showed neuritogenic activity against Neuro 2a cells.
- 公益社団法人日本薬学会の論文
- 2008-06-01
著者
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HIGUCHI RYUICHI
Faculty of Pharmaceutical Sciences, Kyushu University
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MIYAMOTO Tomofumi
Graduate School of Pharmaceutical Sciences, Kyushu University
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HIGUCHI Ryuichi
Graduate School of Pharmaceutical Sciences, Kyushu University
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Van Soest
Institute For Biodiversity And Ecosystem Dynamics University Of Amsterdam
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Miyamoto Tomofumi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Higuchi Ryuichi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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ZHANG Bo
Graduate School of Pharmaceutical Sciences, Kyushu University
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Zhang Bo
Graduate School Of Pharmaceutical Sciences Kyushu University
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Miyamoto T
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Maruta Tomoki
Graduate School Of Pharmaceutical Sciences Kyushu University
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VAN SOEST
Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam
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Zhang Bo
Graduate School of Engineering, Shizuoka University
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