Constituents of Holothuroidea, 17. Isolation and Structure of Biologically Active Monosialo-Gangliosides from the Sea Cucumber Cucumaria echinata
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概要
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Three new monosialo-gangliosides, CEG-3 (3), CEG-4 (4), and CEG-5 (5), were obtained, together with two known gangliosides, SJG-1 (1) and CG-1 (2), from the lipid fraction of the chloroform/methanol extract of the sea cucumber Cucumaria echinata. The structures of the new gangliosides were determined on the basis of chemical and spectroscopic evidence to be 1-O-[4-O-acetyl-α-L-fucopyranosyl-(1→11)-(N-glycolyl-α-D-neuraminosyl)-(2→6)-β-D-glucopyranosyl]-ceramide (3) and 1-O-[α-L-fucopyranosyl-(1→11)-(N-glycolyl-α-D-neuraminosyl)-(2→6)-β-D-glucopyranosyl]-ceramide (4, 5). The ceramide moieties of each compound were composed of heterogeneous sphingosine or phytosphingosine bases, and 2-hydroxy or nonhydroxylated fatty acid units. These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor.
- 公益社団法人日本薬学会の論文
- 2006-07-01
著者
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INAGAKI MASANORI
Faculty of Pharmaceutical Sciences, Kyushu University
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HIGUCHI RYUICHI
Faculty of Pharmaceutical Sciences, Kyushu University
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HIGUCHI Ryuichi
Graduate School of Pharmaceutical Sciences, Kyushu University
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YAMADA Koji
Faculty of Engineering, Saitama University
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Miyamoto Tomofumi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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INAGAKI Masanori
Graduate School of Pharmaceutical Sciences, Kyushu University
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Higuchi Ryuichi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Higuchi Ryuichi
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamada K
Graduate School Of Pharmaceutical Sciences Kyushu University
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MIYAMOTO Tomofumi
Faculty of Pharmaceutical Sciences, Kyushu University
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KISA Fumiaki
Faculty of Pharmaceutical Sciences, Kyushu University
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Miyamoto T
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Yamada Katsuya
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Kisa Fumiaki
Faculty Of Pharmaceutical Sciences Kyushu University
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Inagaki Masanori
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamada Kenji
Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy
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Maruta Tomoki
Graduate School Of Pharmaceutical Sciences Kyushu University
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Ito Masaki
The First Department Of Internal Medicine Mie University School Of Medicine
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Inagaki M
Graduate School Of Pharmaceutical Sciences Chiba University
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Yamada Koji
Faculty Of Engineering Saitama University
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