Biologically Active Glycosides from Asteroidea, 42. Isolation and Structure of a New Biologically Active Ganglioside Molecular Species from the Starfish Asterina pectinifera
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概要
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A ganglioside molecular species GP-3 (1) has been obtained from the water-soluble lipid fraction of the chloroform/methanol extract of the starfish Asterina pectinifera. The structure of the ganglioside has been determined on the basis of chemical and spectroscopic evidence. Compound 1 represents new ganglioside molecular species possessing two moles of sialic acids at the inner part of the sugar moiety. Partial hydrolysis by hot water and an enzymatic hydrolysis by means of endoglycoceramidase (EGCase) have proved useful for structure elucidation of the complex oligosaccharide moiety. Moreover, 1 exhibits neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cells, in the presence of nerve growth factor (NGF).
- 2006-03-01
著者
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INAGAKI MASANORI
Faculty of Pharmaceutical Sciences, Kyushu University
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HIGUCHI RYUICHI
Faculty of Pharmaceutical Sciences, Kyushu University
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HIGUCHI Ryuichi
Graduate School of Pharmaceutical Sciences, Kyushu University
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Isobe R
Department Of Medical Electronics Engineering Faculty Of Engineering Towa University
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Isobe Ryuichi
Tohwa University
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Miyamoto Tomofumi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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INAGAKI Masanori
Graduate School of Pharmaceutical Sciences, Kyushu University
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Higuchi Ryuichi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Higuchi Ryuichi
Faculty Of Pharmaceutical Sciences Kyushu University
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Inagaki Kouji
Faculty Of Pharmaceutical Sciences Kyushu University
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MIYAMOTO Tomofumi
Faculty of Pharmaceutical Sciences, Kyushu University
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ISOBE Ryuichi
Department of Medical Electronics Engineering, Faculty of Engineering, Towa University
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Miyamoto T
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Isobe Ryuichi
Department Of Medical Electronics Engineering Faculty Of Engineering Towa University
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Isobe R
Faculty Of Pharmaceutical Sciences Kyushu University
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Inoue Shinichi
Faculty Of Pharmaceutical Sciences Kyushu University
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SAKAI Maki
Faculty of Pharmaceutical Sciences, Kyushu University
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KOMORI Tetsuya
Faculty of Pharmaceutical Sciences, Kyushu University
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Sakai Maki
Faculty Of Pharmaceutical Sciences Kyushu University
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Komori Tetsuya
Faculty Of Pharmaceutical Sciences Kyushu University
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Inagaki Masanori
Faculty Of Pharmaceutical Sciences Kyushu University
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Maruta Tomoki
Graduate School Of Pharmaceutical Sciences Kyushu University
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Ito Masaki
The First Department Of Internal Medicine Mie University School Of Medicine
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Shiizaki Masahide
Faculty Of Pharmaceutical Sciences Kyushu University
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Inagaki M
Graduate School Of Pharmaceutical Sciences Chiba University
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