Four New Cembrane Diterpenes Isolated from an Okinawan Soft Coral Lobophytum crassum with Inhibitory Effects on Nitric Oxide Production

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概要

• 論文の詳細を見る

• Four new cembrane diterpenes (1—4) and fifteen known cembranoids (5—19) were isolated from an Okinawan soft coral Lobophytum crassum. The structures of these four new cembranoids were determined on the basis of spectroscopic evidence. In particular, the absolute stereochemistry of 1, 2, 5 and 6 were elucidated by the application of the modified Moshers method and circular dichroism (CD) spectral data. The inhibitory effects of some isolates were evaluated on nitric oxide (NO) production against a murine macrophage-like cell line (Raw 264.7). Cembranoids consisting of α-methylene-γ-lactone, exhibited the significant effect on NO production.

• 公益社団法人　日本薬学会の論文

著者

• Miyamoto Tomofumi

  Graduate School Of Pharmaceutical Sciences Kyushu Univ.

• Higuchi Ryuichi

  Graduate School Of Pharmaceutical Sciences Kyushu Univ.

• Tanaka Chiaki

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Wanzola Mpanzu

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Furuta Takaaki

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Kohno Yasuhisa

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Fukumitsu Shunichi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Yasukochi Shuhei

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Watari Kosuke

  Graduate School of Pharmaceutical Sciences, Kyushu University

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