Biologically Active Glycosides from Asteroidea, 43. : Isolation and Structure of a New Neuritogenic-Active Ganglioside Molecular Species from the Starfish Linckia laevigata
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概要
- 論文の詳細を見る
A ganglioside molecular species, LLG-5 (1), has been obtained from the water soluble lipid fraction of the CHCl_3/MeOH extract of the starfish Linckia laevigata. On the basis of chemical and spectroscopic findings, the structure of 1 has been elucidated. Negative ion FAB-MS provided important information both on the structure of the sugar moiety and on the molecular mass of the ganglioside. 1 is a new ganglioside molecular species possessing a 2→11 linked linear-type trisialosyl moiety. Moreover, 1 exhibited neuritogenic activity in rat pheochromocytoma PC-12 cells in the presence of nerve growth factor.
- 2005-12-01
著者
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INAGAKI MASANORI
Faculty of Pharmaceutical Sciences, Kyushu University
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HIGUCHI RYUICHI
Faculty of Pharmaceutical Sciences, Kyushu University
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MIYAMOTO Tomofumi
Graduate School of Pharmaceutical Sciences, Kyushu University
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HIGUCHI Ryuichi
Graduate School of Pharmaceutical Sciences, Kyushu University
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Isobe R
Department Of Medical Electronics Engineering Faculty Of Engineering Towa University
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Isobe Ryuichi
Tohwa University
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Miyamoto Tomofumi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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INAGAKI Masanori
Graduate School of Pharmaceutical Sciences, Kyushu University
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Higuchi Ryuichi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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ISOBE Ryuichi
Department of Medical Electronics Engineering, Faculty of Engineering, Towa University
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Miyamoto T
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Isobe Ryuichi
Department Of Medical Electronics Engineering Faculty Of Engineering Towa University
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Isobe R
Faculty Of Pharmaceutical Sciences Kyushu University
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Inagaki Masanori
Graduate School Of Pharmaceutical Sciences Kyushu University
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Maruta Tomoki
Graduate School Of Pharmaceutical Sciences Kyushu University
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Ito Masaki
The First Department Of Internal Medicine Mie University School Of Medicine
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Inagaki M
Graduate School Of Pharmaceutical Sciences Chiba University
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