NOVEL PREPARATION OF FREE FLOWING SPHERICALLY GRANULATED DIBASIC CALCIUM PHOSPHATE ANHYDROUS FOR DIRECT TABLETTING
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概要
- 論文の詳細を見る
Free flowing spherically granulated (average diameter, 70 or 115 μm) dibasic calcium phosphate anhydrous (DCPA) for direct tabletting was prepared by a restricted crystal growing synthesis of DCPA, followed by spray drying of its aqueous dispersions. The spherically granulated DCPA had larger specific suraface area (32 to 34 m^2/g), because they had porous structures compoesd of very fine primary crystals (Heywood diameter, 0.1-1.0 μm) compared to conventionally prepared DCPA (Heywood diameter, 2.0-5.0 μm). The crystallinity of granulated DCPA was lower than that of conventional DCPA. Those micromeritic characteristics of granulated DCPA might correlated closely with their dramatically improved tablettability.
- 公益社団法人日本薬学会の論文
- 1996-04-15
著者
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KAWASHIMA Yoshiaki
Gifu Pharmaceutical University
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TAKAMI Kiyoshi
Fuji Chemical Industry Co., Ltd.,
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MACHMURA Hitoshi
Fuji Chemical Industry Co., Ltd.,
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TAKADO Kenemasa
Fuji Chemical Industry Co., Ltd.,
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INAGAKI Michiji
Fuji Chemical Industry Co., Ltd.,
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Ito Masaki
The First Department Of Internal Medicine Mie University School Of Medicine
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