Tabletting of Solid Dispersion Particles Consisting of Indomethacin and Porous Silica Particles
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概要
- 論文の詳細を見る
We attempted to make the rapidly dissolving tablet (Tab) containing solid dispersion particles (SD) with indomethacin (IMC) and porous silica (Sylysia350) as carrier prepared by using spray-drying technique. Rapidly dissolving tablet was formulated with mannitol as a diluent and low substituted hydroxypropylcellulose (L-HPC) or partly pre-gelatinized starch (PCS) as a disintegrant. The percent dissolved from Tab (SD) was higher than that of tablet containing physical mixture (PM) at 20min. Nearly 100% of drug in Tab (SD) was dissolved within 60min, while the drug dissolution of Tab (PM) was not completed at the same time period. In addition, the tensile strength of Tab (SD) was much higher than that of Tab (PM). Adding L-HPC in Tab (SD) (Tab (SD-L-HPC)), the percent dissolved from Tab (SD-L-HPC) at 5min became much higher than that from Tab (SD). The dissolution profile of IMC from Tab (SD-L-HPC) was almost the same irrespective of the compression pressure, while the tensile strength of tablet increased with increasing the compression pressure. In comparing the compaction property of these tablets by observing the ratio of residual die wall pressure (RDP) to maximum die wall pressure (MDP) (RDP/MDP), it was found that addition of L-HPC in the tablet formulation improved compactibility. In case that PCS was formulated as disintegrant, Tab (SD-PCS), similar improvement in the dissolution profile and tensile strength was observed, though the dissolution rate of IMC from Tab (SD-PCS) was slightly lower than that from Tab (SD-L-HPC) irrespective of the compression pressure.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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Kawashima Y
Taisho Pharmaceutical Co. Ltd. Saitama Jpn
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Yamamoto Hiromitsu
Department Of Pharmaceutical Engineering Gifu Pharmaceutical University
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Yamamoto Hiromitsu
中華人民共和国
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Nagira Shinsuke
Formulation Res. Laboratories Kawashima Res. Eisai Co. Ltd.
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TAKEUCHI Hirofumi
Department of Pharmaceutical Engineering, Gifu Pharmaceutical University
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KAWASHIMA Yoshiaki
Department of Pharmaceutical Engineering, Gifu Pharmaceutical University
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Takeuchi H
Gifu Pharmaceutical Univ.
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TAKEUCHI Hirofumi
Gifu Pharmaceutical University
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NAGIRA Shinsuke
Gifu Pharmaceutical University
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TANIMURA Shinji
Gifu Pharmaceutical University
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YAMAMOTO Hiromitsu
Gifu Pharmaceutical University
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KAWASHIMA Yoshiaki
Gifu Pharmaceutical University
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Kawashima Y
Department Of Pharmaceutical Engineering Gifu Pharmaceutical University
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Takeuchi Hirofumi
Gifu Pharmaceutical Univ.
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Kawashima Y
Gifu Pharmaceutical University
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Takeuchi H
Gifu Pharmaceutical University
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Yamamoto H
Department Of Bioengineering Soka University
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- Preface