Formulation Design of Ointment Base Suitable for Healing of Lesions in Treatment of Bedsores
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概要
- 論文の詳細を見る
We intended to develop a desired ointment base suitable for treatment of bedsores including the proliferation of granulation and epidermis. The main bedsore bacteria detected in our hospital were S.aureus in grampositive coccus and P.aeruginosa in gram-negative bacillus. As the macrogol ointment(MO) was found to have bactericidal effects on these bacteria, MO was adopted as the base for the objective ointment. To improve the properties of the ointment base such as regulating the humidity of the exudation and controlling the release of antibiotics formulated in the ointment, co-formulating effects of various additives to MO were evaluated. The sustained release function of the ointment base was obtained by adding hydrophilic petrolatum(HP) to MO. However, the resultant ointment was found to have a poor humidity regulating property. On the other hand, MO containing 5% of hydroxypropyl cellulose(HPC) showed both the humidity regulating and the controlled drug releasing properties. It was considered that HPC particles dispersed in the ointment could be swelled by absorbing water to form a gel network. The curd tension meter tests for the ointments prepared with the various polymers showed that the MO-HPC base, which showed the highest sustained drug releasing property, was found to have the highest hardness. This result means that HPC formulated into the base forms the most rigid get structure to resist the erosion of the ointment and to control the drug release.
- 社団法人日本薬学会の論文
- 2001-02-01
著者
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Kawashima Y
Taisho Pharmaceutical Co. Ltd. Saitama Jpn
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HINO Tomoaki
Department of Nuclear Engineering, Hokkaido University
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Hino T
Department Of Pharmaceutical Engineering Gifu Pharmaceutical University
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TAKEUCHI Hirofumi
Department of Pharmaceutical Engineering, Gifu Pharmaceutical University
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KAWASHIMA Yoshiaki
Department of Pharmaceutical Engineering, Gifu Pharmaceutical University
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SHIGEYAMA Masato
Department of Pharmacy, Takayama Red Cross Hospital
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OHGAYA Toyoaki
Department of Pharmacy, Takayama Red Cross Hospital
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Takeuchi H
Gifu Pharmaceutical Univ.
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Kawashima Y
Department Of Pharmaceutical Engineering Gifu Pharmaceutical University
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Hino Tomoaki
Department Of Pharmaceutical Engineering Gifu Pharmaceutical University
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Hino Tomoaki
Department Of Nuclear Engineering Hokkaido University
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Takeuchi Hirofumi
Department Of Pharmaceutical Engineering Gifu Pharmaceutical University
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Kawashima Yoshiaki
Department Of Pharmaceutical Engineering Gifu Pharmaceutical University
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Kawashima Y
Gifu Pharmaceutical University
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Takeuchi Hirofumi
Department of Drug Delivery Technology and Science, Pharmaceutical Engineering, Gifu Pharmaceutical University
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