Mixed Base of Hydrophilic Ointment and Purified Lanolin to Improve the Drug Release Rate and Absorption of Water of Minocycline Hydrochloride Ointment for Treatment of Bedsores

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概要

• 論文の詳細を見る

• A desired ointment bases for better treatment of bedsores was developed to improve the release rate of minocycline hydrochloride (MH) and the water absorption capacity using various types of hydrophobic to hydrophilic ointment base. The influence of purified lanolin (PL) on the release behavior of MH from hydrophilic ointment (HO) base was primarily focused on. It wsa found that the release rate of drug increased with increase in the hydrophilicity of the base. A linear correlation between the apparent release rate constant of drug from the HO and PL mixed ointment base at various combination ratios and the elution of ointment base was noted.The HO ointment base containing 30% PL had the highest apparent release rate constant of MH. The mixed ointment base with the lowest viscosity showed the highest absorption of water and elution of ointment base. In conclusion, it was found that HO (70%) and PL (30%) mixed ointment base was a promising candidate for better treatment of bedsores.

• 公益社団法人日本薬学会の論文
• 1999-06-15

著者

• SHIGEYAMA Masato

  Department of Pharmacy, Takayama Red Cross Hospital

• OHGAYA Toyoaki

  Department of Pharmacy, Takayama Red Cross Hospital

• Takeuchi H

  Gifu Pharmaceutical Univ.

• Hino Tomoaki

  Department Of Nuclear Engineering Hokkaido University

• Takeuchi Hirofumi

  Department Of Pharmaceutical Engineering Gifu Pharmaceutical University

• Kawashima Yoshiaki

  Department Of Pharmaceutical Engineering Gifu Pharmaceutical University

• Kawashima Y

  Gifu Pharmaceutical University

• Takeuchi Hirofumi

  Department of Drug Delivery Technology and Science, Pharmaceutical Engineering, Gifu Pharmaceutical University

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