Temperature-Induced Crystallization and Compactibility of Spray Dried Composite Particles Composed of Amorphous Lactose and Various Types of Water-Soluble Polymer

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概要

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• The purpose of this study was to investigate the temperature-induced crystallization and the compactivility of the composite particles containing amorphous lactose and various types of polymers. The composite particles were prepared by spray-drying an aqueous solution of lactose and various types of gel forming water-soluble polymers at various formulating ratios.The stabilizing effect of hydroxypropylcellulose (HPC) and polyvinyl pyrrolidone (PVP) on amorphous lactose in the composite particles was smaller than that of sodium alginate in comparing at the same formulating ratios. The defference in the stability of amorphous lactose in the composite particles was attributed to the difference in the glass transition temperature (Tg) of the composite particles caused by the polymers formulated. The tensile strength of compacted spray-dried composite particles containing the polymers was highter than commercial lactose for direct tabletting (DCL21). The tensile strength of the composite particles was increased with an increase in water content in the particles. The difference in compactibility of the composite particls containing the different amount of polymer and water could be explained by the difference in Tg of the particles.

• 公益社団法人日本薬学会の論文
• 2000-04-01

著者

• Yamamoto Hiromitsu

  Department Of Pharmaceutical Engineering Gifu Pharmaceutical University

• Yamamoto Hiromitsu

  中華人民共和国

• Takeuchi H

  Gifu Pharmaceutical Univ.

• TAKEUCHI Hirofumi

  Gifu Pharmaceutical University

• YAMAMOTO Hiromitsu

  Gifu Pharmaceutical University

• KAWASHIMA Yoshiaki

  Gifu Pharmaceutical University

• Takeuchi Hirofumi

  Gifu Pharmaceutical Univ.

• Kawashima Y

  Gifu Pharmaceutical University

• YASUJI Takehiko

  Gifu Pharmaceutical University

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• Preface

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