Asymmetric Borane Reduction of Prochiral Ketone Using Chiral Bis(α,α-diphenyl-2-pyrrolidinemethanol) Carbonate
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概要
- 論文の詳細を見る
Chiral bis(α,α-diphenyl-2-phyrrolidinemethanol) carbonate (DPP_2・H_2CO_3) is a useful asymmetric auxiliary for the asymmetric borane reduction of prochiral ketones. Chiral DPP_2・H_2CO_3 is recoverable from the reaction and directly reusable for the reaction. The intermediate of KUR-1246, which we are developing as a new uterine relaxant, was synthesized using the methodology.
- 公益社団法人日本薬学会の論文
- 2003-02-01
著者
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TAKEUCHI Hirofumi
Gifu Pharmaceutical University
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Ishikawa Tsutomu
Dep. Of Medicinal Organic Chemistry Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Ishikawa Tsutomu
Graduate School Of Pharmaceutical Sciences Chiba University
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Yanagi Toshiharu
Nagase Chemtex Corporation Kobe Product Development Center
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Yanagi Toshiharu
Department Of Chemistry University Of Tsukuba
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Yanagi Takashi
Central Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Ishikawa T
Graduate School Of Pharmaceutical Sciences Chiba University
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KIKUCHI Ken
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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TAKEUCHI Hideki
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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ISHIKAWA Takehiro
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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NISHIMURA Toshihiro
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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KUBOTA Minoru
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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YAMAMOTO Iwao
Faculty of Textile Science and Technology, Shinshu University
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Kikuchi K
Graduate School Of Pharmaceutical Sciences The University Of Tokyo:presto Jst Corporation
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Yamaguchi T
Tsumura Res. Laboratories Tsumura & Co.
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Nishimura T
Central Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Yamamoto I
Faculty Of Textile Science And Technology Shinshu University
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Nishimura T
Waseda University Graduate School Information Architecture
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Ishikawa Tsutomu
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Yamamoto Iwao
Faculty Of Textile Science And Technology Shinshu University
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Kubota Minoru
Central Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Ishikawa Toshihisa
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
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Ishikawa Toshihisa
Graduate School of Pharmaceutical Sciences, Chiba University
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