A Novel Fluorescent Probe for Zinc Ion Based on Boron Dipyrromethene (BODIPY) Chromophore
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概要
- 論文の詳細を見る
ZnAB has the combined structure of N, N-bis(2-pyridylmethyl)ethylenediamine as a specific chelater for Zn^<2+> and 1, 3, 5, 7-tetramethyl-8-phenyl-boron dipyrromethene as a fluorophore. Complexation of ZnAB with Zn^<2+> produces a remarkable enhancement of fluorescence intensity. ZnAB has the advantages of less sensitivity to solvent polarity and ph than fluorescein-based Zn^<2+> probes. Furthermore, it is not influenced by other cations, such as Na^+, K^+, Ca^<2+>, and Mg^<2+>, which exist at high concentrations under physiological conditions, even at 2.5 mM. The results show that ZnAB is a Zn^<2+> probe suitable for biological applications.
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
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Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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浦野 泰照
東京大学大学院薬学系研究科
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NAGANO Tetsuo
Graduate School of Pharmaceutical Sciences, University of Tokyo
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Hirano Tomohisa
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Hirano Toshihiko
Tokyo Univ. Medical Univ. Pharmacy And Life Sci. Tokyo Jpn
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Hirano Toshihiko
Department Of Clinical Pharmacology Tokyo University Of Pharmacy And Life Science
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FUKASAKU NOBORU
Daiichi Pure Chemical Co., Ltd.
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KOJIMA Hirotatsu
Graduate School of Pharmaceutical Sciences
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KIKUCHI Kazuya
Graduate School of Pharmaceutical Sciences
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URANO Yasuteru
Graduate School of Pharmaceutical Sciences
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KOUTAKA Hitomi
Daiichi Pure Chemicals Co., Ltd.
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KOSUGE Jun-ichi
Daiichi Pure Chemicals Co., Ltd.
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HIRANO Tomoya
Graduate School of Pharmaceutical Sciences, the University of Tokyo
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Nagao T
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kikuchi K
Graduate School Of Pharmaceutical Sciences The University Of Tokyo:presto Jst Corporation
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Kikuchi Kazuya
Graduate School Of Engi Neering Osaka University:immunology Frontier Research Center Osaka Universit
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Nagano T
Lab. Of Chemistry And Biology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo
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Nagano Tetsuo
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Urano Yasuteru
Graduate School Of Pharmaceutical Sciences University Of Tokyo
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Fukasaku N
Daiichi Pure Chemicals Co. Ltd.
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Fukasaku Noboru
Daiichi Pure Chemical Co. Ltd.
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Kojima H
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Hirano T
Department Of Clinical Pharmacology Tokyo University Of Pharmacy And Life Science
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Kosuge Jun-ichi
Daiichi Pure Chemicals Co. Ltd.
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Koutaka Hitomi
Daiichi Pure Chemicals Co. Ltd.
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