Antiproliferative Constituents in Plants 10. Flavones from the Leaves of Lantana montevidensis BRIQ. and Consideration of Structure-Activity Relationship
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概要
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The flavonoid fraction from the leaves of Lantana montevidensis BRIQ. (Verbenaceae) showed antiproliferative activity against human gastric adenocarcinoma (MK-1, G150: 12 μg/ml), human uterus carcinoma (HeLa, 5 μg/ml), and murine melanoma (B16F10, 5 μg/ml) cells in vitro. Bioactivity-guided chemical investigation of the fraction has resulted in the isolation of apigenin (10) and ten 5,6,7-oxygenated fiavones: cirsilineol (1), eupatorin (2), 5,4'-dihydroxy-6,7,3',5'-tetramethoxyflavone (3), 5,6-dihydroxy-7,3',4'-trimethoxyfiavone (4), 5,6,4'-trihydroxy- 7,3',5'-trimethoxyfiavone (5), 5,6,3'-trihydroxy-7,4'-dimethoxyflavone (6), 5,3',4'-trihydroxy-6,7,5'-trimethoxyflavone (7), cirsiliol (8), hispidulin (9), and eupafolin (11). Antiproliferative activity of the isolated flavones, some other related flavones (luteolin, baicalein, 6-hydroxyluteolin, pectolinarigenin, jaceosidin, desmethoxycentaureidin, eupatilin, and chrysin) from other plant materials, and synthetic 6- and 7-methoxyflavones was evaluated, and the structure-activity relationships were examined.
- 公益社団法人日本薬学会の論文
- 2002-07-01
著者
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Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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岡部 光
Faculty Of Pharmaceutical Sciences Fukuoka University
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阿部 フミ子
Faculty Of Pharmaceutical Sciences Fukuoka University
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KINJO Junei
Faculty of Pharmaceutical Sciences, Fukuoka University
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Kinjo Junei
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
福岡大学 薬学部
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Kinjo Junei
熊本大学 薬
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ABE Fumiko
Faculty of Pharmaceutical Sciences, Fukuoka University
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OKABE Hikaru
Faculty of Pharmaceutical Sciences, Fukuoka University
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NAGAO Tsuneatsu
Faculty of Pharmaceutical Sciences, Fukuoka University
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Okabe Hikaru
Faculty Of Pharmaceutical Sciences Fukuoka University
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岡部 光
福岡大学
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Okabe Hikaru
福岡大学 薬学部
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岡部 光
福岡大学薬学部
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金城 順英
熊本大学 薬
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Abe Fumiko
Faculty Of Pharmaceutical Science Fukuoka University
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Kinjo J
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kim J-h
Faculty Of Pharmaceutical Sciences Fukuoka University
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Nagao T
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjyo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
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Nagao Tsuneatsu
Faculty Of Pharmaceutical Sciences Fukuoka University
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