Antiproliferative Activity of the Main Constituents from Phyllanthus emblica

スポンサーリンク

概要

• 論文の詳細を見る

• Eighteen main compounds, including four norsesquiterpenoids (1?4) and 14 phenolic compounds (5?18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5?8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.

• 社団法人日本薬学会の論文
• 2004-02-01

著者

• 田中 隆

  長崎大学大学院医歯薬学総合研究科

• Nagamatsu T

  Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University

• Nagao Toshiyuki

  Department Of Pharmacology Faculty Of Pharmacy Meijo University

• Nagamatsu T

  Department Of Pharmacology Faculty Of Pharmacy Meijo University

• 岡部 光

  Faculty Of Pharmaceutical Sciences Fukuoka University

• OKABE Hikaru

  Faculty of Pharmaceutical Sciences, Fukuoka University

• NAGAO Tsuneatsu

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Okabe Hikaru

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 岡部 光

  福岡大学

• Okabe Hikaru

  福岡大学 薬学部

• 岡部 光

  福岡大学薬学部

• Yang C‐r

  Laboratory Of Phytochemistry Kunming Institute Of Botany Chinese Academy Of Sciences

• Zhang Y‐j

  Laboratory Of Phytochemistry Kunming Institute Of Botany Chinese Academy Of Sciences

• ZHANG Ying-Jun

  Faculty of Pharmaceutical Sciences, Nagasaki University

• TANAKA Takashi

  Faculty of Pharmaceutical Sciences, Nagasaki University

• YANG Chong-Ren

  State Key Laboratory of Phytochemistry Plant Resources in West China, Kunming Institute of Botany, C

• KOUNO Isao

  Faculty of Pharmaceutical Sciences, Nagasaki University

• Yang Chong-ren

  State Key Laboratory Of Phytochemistry And Plant Resources In West China Kunming Institute Of Botany

• Kouno I

  Nagasaki Univ. Nagasaki Jpn

• Kouno Isao

  Graduate School Of Biomedical Sciences Nagasaki University

• Kouno Isao

  Course Of Pharmaceutical Sciences Graduate School Of Biomedical Sciences Nagasaki University

• Kouno Isao

  Faculty Of Pharmaceutical Sciences Nagasaki University

• Tanaka Tomonori

  Faculty Of Medical And Pharmaceutical Sciences Kumamoto University

• 田中 隆

  Faculty Of Pharmaceutical Sciences Kyushu University

• Nagao T

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Nagao Tsuneatsu

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Tanaka Takemi

  School Of Agriculture Kyushu Tokai University

• Tanaka Takashi

  Faculty Of Pharmaceutical Sciences Nagasaki University

関連論文

• Penicillium、FusariumまたRoselliniaにより発酵処理した緑茶エキスの化学成分
• セイタカアワダチソウの組織培養とポリフェノール類生産
• ゲラニイン含有植物の加工処理と生成物の解析
• Hemiphragma heterophyllumの新規フェニルエタノイド配糖体
• オートクレーブ処理した茶葉および茶ドリンクのカテキン成分
• ナス(Solanum melongena L.)培養組織の成分解析
• 三番茶葉とビワ葉を混合揉捻した新たな発酵茶の開発
• Tannins and Related Compounds. CXXIV. Five New Ellagitannins, Platycaryanins A, B, C, and D, and Platycariin, and a New Complex Tannin, Strobilanin, from the Fruits and Bark of Platycarya strobilacea SIEB et ZUCC., and Biomimetic Synthesis of C-Glycosidic
• Inhibitory Effects of Tannins on NADH Dehydrogenases of Various Organisms
• Tannins and Related Compounds. CXXIII. Chromone, Acetophenone and Phenylpropanoid Glycosides and Their Galloyl and/or Hexahydroxydiphenoyl Esters from the Leaves of Syzygium aromaticum MERR. et PERRY
• Tannins and Related Compounds. CXXII. New Dimeric, Trimeric and Tetrameric Ellagitannins, Lambertianins A-D, from Rubus lambertianus SERINGE
• Tannins and Related Compounds. CXVII. Isolation and Characterization of Three New Ellagitannins, Lagerstannins A, B and C, Having a Gluconic Acid Core, from Lagerstroemia speciosa (L.) PERS
• Tannins and Related Compounds. CXVIII. Structures, Preparation, High-Performance Liquid Chromatography and Some Reactions of Dehydroellagitannin-Acetone Condensates
• Tannins and Related Compounds. CXVI. Six New Complex Tannins, Guajavins, Psidinins and Psiguavin from the Bark of Psidium guajava L.
• Tannins and Related Compounds. CVIII. Isolation and Characterization of Novel Complex Tannins (Flavono-ellagitannins), Anogeissinin and Anogeissusins A and B, from Anogeissus acuminata (ROXB ex DC.) GUILL. et PERR. var. lanceolata WALL. ex CLARKE
• Tannins and Related Compounds. CVII. Structure Elucidation of Three New Monomeric and Dimeric Ellagitannins, Flosin B and Reginins C and D, Isolated from Lagerstroemia flos-reginae RETZ.
• Tannins and Related Compounds. CVI. Preparation of Aminoalditol Derivatives of Hydrolyzable Tannins Having α-and β-Glucopyranose Cores, and Its Application to the Structure Elucidation of New Tannins, Reginins A and B and Flosin A, Isolated from Lagerstro
• 目で見る漢方薬・生薬(12)芍薬
• 植物ポリフェノールに関する化学的研究とその紅茶色素生成機構解明への展開
• ポリマー断片化によるプロアントシアニジンオリゴマーの製造方法
• P-21 紅茶色素形成に関わるエピガロカテキン由来ビシクロ[3.2.1]オクタン骨格を持つ鍵中間体の生成分解機構(ポスター発表の部)
• Antibacterial Spectrum of Plant Polyphenols and Extracts Depending upon Hydroxyphenyl Structure
• P-69 紅茶ポリフェノールの生成機構 : カテキン酸化カスケード(ポスター発表の部)
• Antimicrobial Activity of 10 Different Plant Polyphenols against Bacteria Causing Food-Borne Disease
• 105(P-44) エピガロカテキンの新しい酵素酸化機構(ポスター発表の部)
• 51(P-17) 紅茶に含まれるエピガロカテキン二量体テアシネンシン類の生成機構(ポスター発表の部)
• 緑茶カテキンの酸化と紅茶色素の生成
• 56(P-13) カテキン及び関連ポリフェノールの酸化メカニズム(ポスター発表の部)
• 86(P-89) 茶葉発酵時におけるカテキン類酸化過程の化学的解析(ポスター発表の部)
• 生薬の効き目を科学する : その最前線から
• P-42 温脾湯の抗酸化及びラジカル消去活性成分
• 茶葉とビワ葉の混合発酵茶に含まれる香気成分の特性
• 混合発酵茶の製造法と発酵におけるビワ葉の役割 (特集 健康機能性食品の開発)
• ナス(Solanum melongena L.)培養組織の成分解析
• 三番茶葉とビワ葉を混合揉捻した新たな発酵茶の開発
• ウスバサイシンAsiasarum sieboldii F. Maekawaの発芽特性
• A New Lignan Glycoside and Phenylethanoid Glycosides from Strobilanthes cusia BREMEK
• DPPH radical-scavenging effect on some constituents from the aerial parts of Lippia triphylla
• Antioxidative and Antihyaluronidase Activities of Some Constituents from the Aerial Part of Daucus carota
• 7-O-Galloyl-D-sedoheptulose Is a Novel Therapeutic Agent against Oxidative Stress and Advanced Glycation Endproducts in the Diabetic Kidney(Pharmacognosy)
• Protective Effects of Morroniside Isolated from Corni Fructus against Renal Damage in Streptozotocin-Induced Diabetic Rats
• Identification of Antidiabetic Effect of Iridoid Glycosides and Low Molecular Weight Polyphenol Fractions of Corni Fructus, a Constituent of Hachimi-jio-gan, in Streptozotocin-Induced Diabetic Rats
• Beneficial Effect of Corni Fructus, a Constituent of Hachimi-jio-gan, on Advanced Glycation End-product-Mediated Renal Injury in Streptozotocin-Treated Diabetic Rats
• P-13 漢方湯液中での芍薬タンニンと共存生薬成分の疎水会合の解析
• P-32 クリおよびノグルミ材におけるポリフェノール成分の構造と分布(ポスター発表の部)
• A New Triphenyl-Type Neolignan and a Biphenylneolignan from the Bark of Illicium simonsii
• DIRECT DETERMINATION OF OPIUM ALKALOID-BOVINE SERUM ALBUMIN CONJUGATE BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY
• 81 柿の脱渋機構の化学的解明(ポスター発表の部)
• Tannins and Related Compounds. CV. Monomeric and Dimeric Hydrolyzable Tannins Having a Dehydrohyxahydroxydiphenoyl Group, Supinanin, Euphorscopin, Euphorhelin and Jolkianin, from Euphorbia Species
• Tannins and Related Compounds. CIII. Isolation and Characterizatino of New Monomeric, Dimeric and Trimeric Ellagitannins, Calamansanin and Calamanins A, B and C, from Terminalia calamansanai (BLANCO) ROLFE
• Tannins and Related Compounds. C. : Reaction of Dehydrohexahydroxydiphenic Acid Esters with Bases, and Its Application to the Structure Determination of Pomegranate Tannins, Granatins A and B
• Tannins and Related Compounds. XCVIII. : Structures of Three New Dimeric Ellagitannins, Excoecarianin and Excoecarinins A and B, Isolated from the Leaves of Excoecaria kawakamii HAYATA
• Tannins and Related Compounds. XCVII. : Structure Revision of C-Glycosidic Ellagitannins, Castalagin, Vescalagin, Casuarinin and Stachyurin, and Related Hydrolyzable Tannins
• Tannins and Related Compounds. XCVI. : Structures of Macaranins and Macarinins, New Hydrolyzable Tannins Possessing Macaranoyl and Tergalloy Ester Groups, from the Leaves of Macaranga sinensis (BAILL.) MUELL.-ARG.
• Tannins and Related Compounds. XCV. : Isolation and Characterization of Helioscopinins and Helioscopins, Four New Hydrolyzable Tannins from Euphorbia helioscopia L. (1)
• Tannins and Related Compounds. XCII. : Isolation and Characterization of Cyanogenic Ellagitannins, Aleurinins A and B, and a Related O-Glycosidic Ellagitannin, Aleurinin C, from Aleurites fordii HEMSLEY
• Effect of Magnesium Lithospermate B on Urinary Excretion of Arachidonate Metabolites in Rats with Renal Failure
• 130) 腎不全ラットに対する丹参成分 Lithospermic acid B Mg 塩の腎機能改善とその作用機序
• A New Method for Structural Study of Hydrolyzable Tannins by Negative Ion Fast Atom Bombardment Mass Spectrometry
• Tannins and Related Compounds. LXXIX. Isolation and Characterization of Novel Dimeric and Trimeric Hydrolyzable Tannins, Nuphrins C, D, E and F, from Nuphar japonicum DC.
• Contribution of Prostaglandins to the Renal Responses to Magnesium Lithospermate B Isolated from Salviae Miltiorrhizae Radix
• Magnesium and Ammonium-Potassium Lithospermates B, the Active Principles Having a Uremia-Preventive Effect from Salvia miltiorrhiza
• Tannins and Related Compounds. LXXV. : Isolation and Characterization of Novel Diastereoisomeric Ellagitannins, Nupharins A and B, and Their Homologues from Nuphar japonicum DC.
• I-A-26 アデニン誘発腎不全ラットに対する丹参成分 Lithospermic acid B Mg 塩の作用その 5
• Synthesis and Analgesic Activity of C-Terminal Fragment Peptides of Cholecystokinin(Medicinal Chemistry,Chemical)
• Tannins and Related Compounds. XLII. : Isolation and Characterization of Four New Hydrolyzable Tannins, Terflavins A and B, Tergallagin and Tercatain from the Leaves of Terminalia catappa L.
• Tannins and Related Compounds. XLI. : Isolation and Characterization of Novel Ellagitannins, Punicacorteins A, B, C, and D, and Punigluconin from the Bark of Punica granatum L.
• Tannins and Related Compounds. XL. : Revision of the Structures of Punicalin and Punicalagin, and Isolation and Characterization of 2-O-Galloylpunicalin from the Bark of Punica granatum L.
• Tannins and Related Compounds. XXI. Isolation and Characterization of Galloyl and p-Hydroxybenzoyl Esters of Benzophenone and Xanthone C-Glucosides from Mangifera indica L.
• Tannins and Related Compounds. XVII. Galloylhamameloses from Castanea crenata L. and Sanguisorba officinalis L.
• Tannins and Related Compounds. XVI. Isolation and Characterization of Six Methyl Glucoside Gallates and a Gallic Acid Glucoside Gallate from Sanguisorba officinalis L.
• A DIMERIC HYDROLYZABLE TANNIN, SANGUIIN H-6 FROM SANGUISORBA OFFICINALIS L.
• Two new maltol glycosides and cyanogenic glycosides from Elsholtzia rugulosa Hemsl.
• Rubusuaviins A-F, Monomeric and Oligomeric Ellagitannins from Chinese Sweet Tea and Their α-Amylase Inhibitory Activity
• Antiproliferative Activity of the Main Constituents from Phyllanthus emblica
• Two New Acylated Flavanone Glycosides from the Leaves and Branches of Phyllanthus emblica
• New Phenolic Constituents from the Fruit Juice of Phyllanthus emblica
• Four New Caffeic Acid Metabolites, Yunnaneic Acids E-H, from Salvia yunnanensis
• Ellagitannins and Lignan Glycosides from Balanophora japonica (Balanophoraceae)
• Caffeoyl, Coumaroyl, Galloyl, and Hexahydroxydiphenoyl Glucoses from Balanophora japonica
• Protective effect of Sanguisorbae Radix against peroxynitrite-mediated renal injury
• A Study on the Nitric Oxide Production-Suppressing Activity of Sanguisorbae Radix Components
• Biflavanones, Diterpenes, and Coumarins from the Roots of Stellera chamaejasme L.
• Activity-Guided Fractionation of Green Tea Extract with Antiproliferative Activity against Human Stomach Cancer Cells
• Revised Structure of Cercidinin A, a Novel Ellagitannin Having (R)-Hexahydroxydiphenoyl Esters at the 3, 4-Positions of Glucopyranose
• Association of Tannins and Related Polyphenols with the Cyclic Peptide Gramicidin S
• Interaction of Peptide Turn Structure with Tannins : Stereochemical Analysis by NMR Spectroscopy
• Interaction of Peptides Having a Turn Structure with Tannins
• Euscaphinin, a new ellagitannin dimer from Euscaphis japonica (THUNB.) KANITZ.
• Polymer-Like Polyphenols of Black Tea and Their Lipase and Amylase Inhibitory Activities
• Structures of Epicatechin Gallate Trimer and Tetramer Produced by Enzymatic Oxidation
• P-217 ACIDIC POLYPHENOLS PRODUCED BY ENZYMATIC OXIDATION OF TEA CATECHINS
• Effects of Iridoids on Lipoxygenase and Hyaluronidase Activities and Their Activation by β-Glucosidase in the Presence of Amino Acids
• Iridoids and Anthraquinones from the Malaysian Medicinal Plant, Saprosma scortechinii (Rubiaceae)
• Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis
• Studies on a Medicinal Parasitic Plant: Lignans from the Stems of Cynomorium songaricum
• Alkaloids, Diarylheptanoid and Naphthalene Carboxylic Acid Ester from Rhoiptelea chiliantha
• A Novel Rearranged Type of Secoeudesmane Sesquiterpenoide from the Root of Lindera strychinifolia (SIEB. et ZUCC.) F. VILLARS
• New Phenylpropanoid Glycosides from the Fruits of Illicium anisatum
• Dammarane-Type Triterpene Glycosides from the Leaves of Rhoiptelea chiliantha

もっと見る 閉じる

スポンサーリンク