Contribution of Prostaglandins to the Renal Responses to Magnesium Lithospermate B Isolated from Salviae Miltiorrhizae Radix

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The involvement of prostanoids in the improvement of adenine-induced renal failure in rats by magnesium lithospermate B was studied. After intraperitoneal administration of magnesium lithospermate B to renal failure rats, the levels of glomerular filtration rate, renal plasma flow and renal blood flow were increased. Urinary excretions of prostaglandin E_2 (PGE_2) and 6-keto-prostaglandin F_<1α> (6-keto-PGF_<1α>) in renal failure rats were increased by the administration of magnesium lithospermate B, while that of thromboxane B_2 had no effect. Pretreatment with indomethacin abolished the improving effect of magnesium lithospermate B on renal function concomitantly with markedly suppressed urinary excretion of prostanoids. These results suggest that the increased formation of PGE_2 and 6-keto-PGF_<1α> might contribute to the improvement of adenine-induced renal failure in rats by magnesium lithospermate B.
社団法人日本薬学会の論文
1989-06-25