Beneficial Effect of Corni Fructus, a Constituent of Hachimi-jio-gan, on Advanced Glycation End-product-Mediated Renal Injury in Streptozotocin-Treated Diabetic Rats

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概要

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• Previous investigations have demonstrated that Hachimi-jio-gan, a Chinese prescription consisting of eight crude drugs, has a therapeutic potential in diabetes and diabetic nephropathy, using these model rats. To add to these findings, we performed this study to assess whether one of the crude drugs, Corni Fructus (Cornus officinalis SIEB. et ZUCC.), had an effect on streptozotocin-induced diabetic rats as a major active constituent, compared with an inhibitor of advanced glycation end-product (AGE) formation, aminoguanidine. Diabetic rats were orally administrated Corni Fructus extract (50, 100, 200 mg/kg body weight/d) or aminoguanidine (100 mg/kg body weight/d). Treatment with Corni Fructus for 10 d suppressed hyperglycemia, proteinuria, renal AGE formation, and related protein expressions, i.e., receptor for AGEs, nuclear factor-κB, transforming growth factor-β1, and Nε-(carboxymethyl)lysine, in the same way as with aminoguanidine. However, improvement of renal function, shown via serum creatinine (Cr) and Cr clearance, was superior to aminoguanidine treatment. In conclusion, the present study supported the hypothesis that Corni Fructus plays an important role against diabetic pathogenesis, i.e., reducing glucose toxicities, up-regulating renal function, and consequently ameliorating glycation-associated renal damage; thus, this study may provide a new recognition of crude drugs to clarify the mechanisms of Chinese prescriptions.

• 社団法人日本薬学会の論文
• 2007-03-01

著者

• Yokozawa Takako

  Institute of Natural Medicine, University of Toyama

• 田中 隆

  長崎大学大学院医歯薬学総合研究科

• Tanaka Takashi

  Graduate School Of Education Hiroshima University

• Kang Ki

  Inst. Of Natural Medicine Univ. Of Toyama

• Kang Ki

  富山大学和漢医薬学総合研究所

• Kang Ki

  Institute of Natural Medicine, University of Toyama

• Yamabe Noriko

  Institute of Natural Medicine, University of Toyama

• Yamabe Noriko

  富山大学和漢医薬学総合研究所

• Yamabe Noriko

  Institute Of Natural Medicine University Of Toyama

• Yokozawa Takako

  Inst. Of Natural Medicine Univ. Of Toyama

• Yoshikawa T

  Institute Of Natural Medicine University Of Toyama

• GOTO Eiko

  Institute of Natural Medicine, University of Toyama

• Goto Eiko

  Institute Of Natural Medicine University Of Toyama

• Yokozawa Takako

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Kang Ki

  Institute Of Natural Medicine University Of Toyama

• 田中 隆

  Faculty Of Pharmaceutical Sciences Kyushu University

• Kang Ki

  Univ. Toyama Toyama Jpn

• 横澤 隆子

  Inst. Of Natural Medicine Univ. Of Toyama

• Tanaka Takemi

  School Of Agriculture Kyushu Tokai University

• Tanaka Takashi

  Graduate School Of Biomedical Sciences Nagasaki University

• Tanaka Takashi

  Graduate School Of Biochemical Science Nagasaki University

• TANAKA Takashi

  Graduate School of Biomedical Sciences, Nagasaki University

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