Effects of Heat-Processed Ginseng and Its Active Component Ginsenoside 20(S)-Rg3 on the Progression of Renal Damage and Dysfunction in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty Rats

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of heat-processed ginseng (HPG) and ginsenoside 20(S)-Rg3 on the progression of renal damage in type 2 diabetic rats were investigated. Twenty-two-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF) rats were divided into 4 orally administered groups: vehicle (diabetic control), HPG water extract (100 mg/kg) and 20(S)-Rg3 (5, 10 mg/kg). Non-diabetic Long-Evans Tokushima Otsuka (LETO) rats were used as a normal group. OLETF rats showed markedly higher blood glucose, triglyceride, and total cholesterol levels than those of LETO rats. The elevated blood glucose level of OLETF rats was significantly lowered by 20(S)-Rg3 administration. The elevated serum triglyceride and total cholesterol levels were significantly reduced by the administrations of HPG and 20(S)-Rg3. The serum levels of thiobarbituric acid-reactive substance, an index of lipid peroxidation, were markedly increased in OLETF compared to LETO rats, but it was significantly reduced by HPG and 20(S)-Rg3 administrations. The urinary protein level, an indicator of advanced diabetic nephropathy, of OLETF rats was 4.4 times higher than in LETO rats, but it was reduced significantly by the administrations of HPG and 20(S)-Rg3. Creatinine clearance of OLETF rats was significantly increased after HPG and 20(S)-Rg3 administrations. The elevation of inducible nitric oxide synthase and Nε-(carboxymethyl)lysine protein expressions in renal tissues of OLETF rats was prevented by 20(S)-Rg3 administration. This study provides scientific evidence that 20(S)-Rg3 prevents the progression of renal damage and dysfunction in type 2 diabetic rats via inhibiting oxidative stress and advanced glycation endproduct formation.

• 日本薬学会の論文

著者

• KIM Hyun

  Department of Internal Medicine, Chonnam National University Hospital

• Yokozawa Takako

  Institute of Natural Medicine, University of Toyama

• Kang Ki

  Institute of Natural Medicine, University of Toyama

• Yamabe Noriko

  Institute of Natural Medicine, University of Toyama

• Park Jeong

  Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University

• Yamabe Noriko

  富山大学和漢医薬学総合研究所

• Yamabe Noriko

  Institute Of Natural Medicine University Of Toyama

• Yokozawa Takako

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Kang Ki

  Institute Of Natural Medicine University Of Toyama

• Kim Hyun

  Department Of Agricultural Biotechnology And Center For Agricultural Biomaterials Seoul National Uni

• Park Jeong

  Research Institute Of Pharmaceutical Sciences And College Of Pharmacy Seoul National University

• Kim Hyun

  Department Of Agricultural Bio-resources National Academy Of Agricultural Science Rural Development

• Kim Hyun

  Department of Advanced Material Engineering, Daejeon University, Daejeon 300-716, Republic of Korea

• Kim Hyun

  Department of Food Science, Jinju National University

関連論文

• Gene cloning and enzymatic properties of hyperthermostable β-glycosidase from Thermus thermophilus HJ6(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
• Long-Term Clinical Course of Patients With Isolated Myocardial Bridge
• Autophagy Inhibition Enhances Apoptosis Induced by Ginsenoside Rk1 in Hepatocellular Carcinoma Cells
• Treatment with NZ-419 (5-Hydroxy-1-methylimidazoline-2,4-dione), a Novel Intrinsic Antioxidant, against the Progression of Chronic Kidney Disease at Stages 3 and 4 in Rats
• Retinyl retinoate induces hyaluronan production and less irritation than other retinoids
• Effects of Heat-Processed Ginseng and Its Active Component Ginsenoside 20(S)-Rg3 on the Progression of Renal Damage and Dysfunction in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty Rats
• Efficacy-based identification of active component of hachimijiogan ameliorating diabetic nephropathy
• 7-O-Galloyl-D-sedoheptulose Is a Novel Therapeutic Agent against Oxidative Stress and Advanced Glycation Endproducts in the Diabetic Kidney(Pharmacognosy)
• Protective Effects of Morroniside Isolated from Corni Fructus against Renal Damage in Streptozotocin-Induced Diabetic Rats
• Protective Effect of Persimmon (Diospyros kaki) Peel Proanthocyanidin against Oxidative Damage under H_2O_2-Induced Cellular Senescence(Pharmacology)
• Hypolipidemic Effects of Sophora flavescens and Its Constituents in Poloxamer 407-Induced Hyperlipidemic and Cholesterol-Fed Rats(Pharmacognosy)
• Identification of Antidiabetic Effect of Iridoid Glycosides and Low Molecular Weight Polyphenol Fractions of Corni Fructus, a Constituent of Hachimi-jio-gan, in Streptozotocin-Induced Diabetic Rats
• Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes
• ESR Study on the Structure and Hydroxyl Radical-Scavenging Activity Relationships of Ginsenosides Isolated from Panax ginseng C. A. MEYER(Pharmacognosy)
• Study on the Hydroxyl Radical Scavenging Activity Changes of Ginseng and Ginsenoside-Rb_2 by Heat Processing(Pharmacognosy)
• Beneficial Effect of Corni Fructus, a Constituent of Hachimi-jio-gan, on Advanced Glycation End-product-Mediated Renal Injury in Streptozotocin-Treated Diabetic Rats
• Protective Effects of Broccoli (Brassica oleracea) against Oxidative Damage in Vitro and in Vivo
• Protective Effect of Sun Ginseng against Diabetic Renal Damage(Pharmacognosy)
• Mustard Leaf Suppresses Nitric Oxide Synthesis by Mouse Macrophages
• Protective Effects of Broccoli (Brassica oleracea) and Its Active Components against Radical-Induced Oxidative Damage
• Protective Effects of Mustard Leaf (Brassica juncea) against Diabetic Oxidative Stress
• Protective Effects of the BuOH Fraction from Mustard Leaf in a Renal Ischemia-Reperfusion Model
• Neuroprotective Effects of Kangen-karyu on Spatial Memory Impairment in an 8-Arm Radial Maze and Neuronal Death in the Hippocampal CA1 Region Induced by Repeated Cerebral Ischemia in Rats
• Protective Effects of a Neutral Polysaccharide Isolated from the Mycelium of Antrodia cinnamomea on Propionibacterium acnes and Lipopolysaccharide Induced Hepatic Injury in Mice
• The Effects of Glycine and L-Arginine on Heat Stability of Ginsenoside Rb_1(Pharmacognosy)
• The Chinese Prescription Wen-Pi-Tang Extract Delays Disease Onset in Amyotrophic Lateral Sclerosis Model Mice While Attenuating the Activation of Glial Cells in the Spinal Cord(Pharmacology)
• Protective Effect of Grape Seed Polyphenols against High Glucose-Induced Oxidative Stress
• Effects of Buckwheat in a Renal Ischemia-Reperfusion Model
• Effects of a Dan Shen component, magnesium lithospermate B, in nephrectomized rats
• Piceatannol Inhibits Melanogenesis by Its Antioxidative Actions(Biochemistry)
• Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids
• PJ-404 Prognosis of Functional Mitral Valve Regurgitation after Aortic Valve Replacement(Valvular herat disease/Pericarditis/Cardiac tumor-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-349 Evaluation of Appropriate Bypass Graft Length in Coronary Artery Bypass Grafting with 64-row Multidetector Computed Tomography(CT/DSA-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Increase in the Free Radical Scavenging Activity of Ginseng by Heat-Processing(Pharmacognosy)
• Clinical course of non-severe aplastic anemia in adults
• Anti-aging Effects of Cyanidin under a Stress-Induced Premature Senescence Cellular System
• Substantial role of locus coeruleus-noradrenergic activation and capsaicin-insensitive primary afferent fibers in bee venom's anti-inflammatory effect
• Radical Scavenging Activity and Inhibition of Advanced Glycation End Products(AGEs) Formation of Lespedeza Cuneata(The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)
• High through-put identification of cytotoxic chikusetsusaponin IVa from heat-processed Achyranthes fauriei roots (The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)
• Attenuation of Renal Ischemia-Reperfusion Injury by Proanthocyanidin-Rich Extract from Grape Seeds
• The Protective Role of Chinese Prescription Kangen-karyu Extract on Diet-Induced Hypercholesterolemia in Rats(Pharmacognosy)
• The Beneficial Effects of Morroniside on the Inflammatory Response and Lipid Metabolism in the Liver of db/db Mice
• Protective Effect of Lipoic Acid against Methylglyoxal-Induced Oxidative Stress in LLC-PK_1 Cells
• TED-AJ03-292 FLOW AND ABSORPTION CHARACTERISTICS OF AMMONIA-WATER MIXTURE IN A SLUG FLOW ABSORBER AT LOW SOLUTION FLOW RATE
• Protective effect of Sanguisorbae Radix against peroxynitrite-mediated renal injury
• A Study on the Nitric Oxide Production-Suppressing Activity of Sanguisorbae Radix Components
• Beneficial Effects of Sanguisorbae Radix in Renal Dysfunction Caused by Endotoxin in Vivo
• Tinospora tuberculata Suppresses Nitric Oxide Synthesis in Mouse Macrophages
• First Indications Demonstrating the Preventive Effects of NZ-419, a Novel Intrinsic Antioxidant, on the Initiation and/or Progression of Chronic Renal Failure in Rats
• Modulation of Oxidative Stress and Melanogenesis by Proanthocyanidins
• Ectopically Erupting First Permanent Molar in Chronic Myelogenous Leukemia
• A Case of Hidroacanthoma Simplex
• Formation of p-Type Hg_Cd_Te Epilayers Grown on CdTe Buffer Layers on GaAs (211) B due to In Situ Thermal Annealing
• 11-O-18 Graded Structure on Bioactive Metal Induced by Chemical Surface Modification
• Anti-tumor Activity of the Ginsenoside Rk1 in Human Hepatocellular Carcinoma Cells through Inhibition of Telomerase Activity and Induction of Apoptosis(Molecular and Cell Biology)
• Reduction of Cisplatin-Induced Nephrotoxicity by Ginsenosides Isolated from Processed Ginseng in Cultured Renal Tubular Cells(Pharmacognosy)
• Fresh and pickled vegetable consumption and gastric cancer in Japanese and Korean populations : A meta-analysis of observational studies
• Beam Smoothing in a Passive Q-Switched Laser with an Additional Stimulated Brillouin Scattering Output Coupler
• Multiple gastrointestinal stromal tumors with a germline c-kit mutation
• Unidirectional Single-Mode 532-nm Nd : YAG Laser Using Intracavity Frequency Doubling in Nonplanar Ring Geometry
• Characteristics of a Birefringence Compensation Scheme in Nd^:YAG Rods Using a Polarization Rotator and Imaging Optics
• Crystallization Behavior of Co_Fe_B_ Electrode Layers in Annealed Magnetic Tunnel Junctions
• γ-Aminobutyric Acid Specifically Inhibits Progression of Tubular Fibrosis and Atrophy in Nephrectomized Rats(Pharmacology)
• Influence of Amla (Emblica officinalis Gaertn.) on Hypercholesterolemia and Lipid Peroxidation in Cholesterol-Fed Rats
• Protective Effects of γ-Aminobutyric Acid in Rats with Streptozotocin-Induced Diabetes
• Study on the Components of Luobuma with Peroxynitrite-Scavenging Activity
• Confirmation that Luobuma ameliorates the deterioration of antioxidant defense in senescence-accelerated mice
• Angiotensin receptor blockers are superior to angiotensin-converting enzyme inhibitors in the suppression of hepatic fibrosis in a bile duct-ligated rat model
• Chinese Prescription Kangen-karyu Ameliorates the Development of Diabetic Hepatic Damages via Regulating Oxidative Stress and Inflammation in the Liver of db/db Mice
• Examination of the Nitric Oxide Production-Suppressing Component in Tinospora tuberculata
• Striation Mechanism and Triggered Striation in Dielectric Microdischarge Plasma : Nuclear Science, Plasmas, and Electric Discharges
• Comparison of the efficacy and safety of different formulations of omeprazole-based triple therapies in the treatment of Helicobacter pylori-positive peptic ulcer
• Protective Role of Glycyrrhizae Radix from Peroxynitrite-induced Renal Oxidative Damages
• Effects of Oriental medicines on the production of advanced glycation endproducts
• ON QUASI-HADAMARD PRODUCTS OF CERTAIN ANALYTIC FUNCTIONS WITH NEGATIVE COEFFICIENTS
• Topical anti-inflammatory and antipruritic effects of Alpinia katsumadai extracts
• Molecular Dynamic Simulation of Coalescence between Silver and Palladium Clusters
• Calcinosis cutis in systemic lupus erythematosus : A case report and review of the published work
• Intraocular Infestation with Thelazia callipaeda
• B-19 Surgical outcome for intractable epilepsy with cortical dysplasia
• Anti-Diabetic Effect of Alkaline-Reduced Water on OLETF Rats
• Association between Helicobacter pylori infection and the risk of gastric cancer in the Korean population : prospective case-controlled study
• Expression of Ski in the Granulosa Cells of Atretic Follicles in the Rat Ovary
• Incinerator Flue Gas Cleaning Using Wet-Type Electrostatic Precipitator
• Present and Future of Dental Anesthesiology in South Korea, and the Role of FADAS
• Cutaneous bronchogenic cyst of the abdominal wall
• Intravenous Sedation in South Korea
• Expression of E- and N-cadherin and clinicopathology in hepatocellular carcinoma
• Amplification without Inversion in the Four-level N-Type ^Rb D_1-Line
• Intermixing Characteristics of Strained-InGaAs/InGaAsP Multiple Quantum Well Structure Using Impurity-Free Vacancy Diffusion
• Design of unique two-bit/cell SONOS flash memory device utilizing an advanced saddle structure(Session4A: Nonvolatile Memory)
• Design of unique two-bit/cell SONOS flash memory device utilizing an advanced saddle structure(Session4A: Nonvolatile Memory)
• Purification and Characterization of Extracellular Medium-Chain-Length Polyhydroxyalkanoate Depolymerase from Pseudomonas sp.RY-1
• Values of zeta functions and class number 1 criterion for the simplest cubic fields
• Heavy Metal Concentrations and Enzyme Activities in Soil from a Contaminated Korean Shooting Range(ENVIRONMENTAL BIOTECHNOLOGY)
• Ex Vivo Expansion of Human Umbilical Cord Blood CD34+ Cells in a Collagen Bead-Containing 3-Dimensional Culture System
• Autophagy Inhibition Enhances Apoptosis Induced by Ginsenoside Rk1 in Hepatocellular Carcinoma Cells
• Comparison of Radiation Element Method and Discrete Ordinates Interpolation Method Applied to Three-Dimensional Radiative Heat Transfer(Advanced Fluid Information)
• BR-P4 Enzyme-catalyzed synthesis of enantiospecific RR-lactide from alkyl lactate using Novozym 435(Section IV Biorefinery)
• 27pSJ-12 Study of A (1520, 3/2^-) photoproduction reaction

もっと見る 閉じる

スポンサーリンク