γ-Aminobutyric Acid Specifically Inhibits Progression of Tubular Fibrosis and Atrophy in Nephrectomized Rats(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
γ-Aminobutyric acid (GABA) was administered orally to rats for 60 d after excision of five-sixths of their kidney volume. A decrease in renal function parameters was observed in these nephrectomized rats. However, the administration of GABA ameliorated renal dysfunction, and a longer administration period of GABA increased its protective effect. In addition, tubular fibrosis was markedly increased at 10 and 60 d in nephrectomized control rats, while GABA administration for 10 d reduced tubular fibrosis to the normal level. Tubular atrophy was markedly induced by nephrectomy, and was significantly reduced by the administration of GABA at 60 d. Furthermore, the nephrectomized control rats exhibited an increased expression level of transforming growth factor-β_1, where GABA significantly decreased it after administration for 10 d. The expression of fibronectin in the tubuli of rats administrated GABA for 60 d was completely and dose-dependently reduced as compared with nephrectomized control rats. However, the improvement effects in glomeruli were less. We also found that GABA_A and GABA_B receptors were specifically localized in tubuli. Specific agonists for GABA_A and GABA_B receptors improved renal function. These results suggest that GABA may have a beneficial effect on renal function in nephrectomized rats by inhibiting fibrosis and atrophy primarily in tubuli, and that it ameliorates losses of renal function in renal failure.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
-
Yokozawa Takako
Institute of Natural Medicine, University of Toyama
-
Kim Mujo
Pharma Foods International Co.
-
Yokozawa Takako
Institute Of Natural Medicine University Of Toyama
-
Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
-
TOHDA Chihiro
Institute of Natural Medicine, University of Toyama
-
SASAKI Sumiyo
Institute of Natural Medicine, University of Toyama
-
Sasaki Sumiyo
Institute Of Natural Medicine University Of Toyama
-
Tohda Chihiro
Institute Of Natural Medicine University Of Toyama
-
Tohda Chihiro
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
-
KIM Mujo
Pharma Foods International
関連論文
- Treatment with NZ-419 (5-Hydroxy-1-methylimidazoline-2,4-dione), a Novel Intrinsic Antioxidant, against the Progression of Chronic Kidney Disease at Stages 3 and 4 in Rats
- Effects of Heat-Processed Ginseng and Its Active Component Ginsenoside 20(S)-Rg3 on the Progression of Renal Damage and Dysfunction in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty Rats
- Efficacy-based identification of active component of hachimijiogan ameliorating diabetic nephropathy
- 7-O-Galloyl-D-sedoheptulose Is a Novel Therapeutic Agent against Oxidative Stress and Advanced Glycation Endproducts in the Diabetic Kidney(Pharmacognosy)
- Protective Effects of Morroniside Isolated from Corni Fructus against Renal Damage in Streptozotocin-Induced Diabetic Rats
- Protective Effect of Persimmon (Diospyros kaki) Peel Proanthocyanidin against Oxidative Damage under H_2O_2-Induced Cellular Senescence(Pharmacology)
- Hypolipidemic Effects of Sophora flavescens and Its Constituents in Poloxamer 407-Induced Hyperlipidemic and Cholesterol-Fed Rats(Pharmacognosy)
- Identification of Antidiabetic Effect of Iridoid Glycosides and Low Molecular Weight Polyphenol Fractions of Corni Fructus, a Constituent of Hachimi-jio-gan, in Streptozotocin-Induced Diabetic Rats
- Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes
- ESR Study on the Structure and Hydroxyl Radical-Scavenging Activity Relationships of Ginsenosides Isolated from Panax ginseng C. A. MEYER(Pharmacognosy)
- Study on the Hydroxyl Radical Scavenging Activity Changes of Ginseng and Ginsenoside-Rb_2 by Heat Processing(Pharmacognosy)
- Beneficial Effect of Corni Fructus, a Constituent of Hachimi-jio-gan, on Advanced Glycation End-product-Mediated Renal Injury in Streptozotocin-Treated Diabetic Rats
- Protective Effects of Broccoli (Brassica oleracea) against Oxidative Damage in Vitro and in Vivo
- Protective Effect of Sun Ginseng against Diabetic Renal Damage(Pharmacognosy)
- Mustard Leaf Suppresses Nitric Oxide Synthesis by Mouse Macrophages
- Protective Effects of Broccoli (Brassica oleracea) and Its Active Components against Radical-Induced Oxidative Damage
- Protective Effects of Mustard Leaf (Brassica juncea) against Diabetic Oxidative Stress
- Protective Effects of the BuOH Fraction from Mustard Leaf in a Renal Ischemia-Reperfusion Model
- Neuroprotective Effects of Kangen-karyu on Spatial Memory Impairment in an 8-Arm Radial Maze and Neuronal Death in the Hippocampal CA1 Region Induced by Repeated Cerebral Ischemia in Rats
- Protective Effects of a Neutral Polysaccharide Isolated from the Mycelium of Antrodia cinnamomea on Propionibacterium acnes and Lipopolysaccharide Induced Hepatic Injury in Mice
- The Effects of Glycine and L-Arginine on Heat Stability of Ginsenoside Rb_1(Pharmacognosy)
- The Chinese Prescription Wen-Pi-Tang Extract Delays Disease Onset in Amyotrophic Lateral Sclerosis Model Mice While Attenuating the Activation of Glial Cells in the Spinal Cord(Pharmacology)
- Protective Effect of Grape Seed Polyphenols against High Glucose-Induced Oxidative Stress
- Effects of Buckwheat in a Renal Ischemia-Reperfusion Model
- Effects of a Dan Shen component, magnesium lithospermate B, in nephrectomized rats
- Piceatannol Inhibits Melanogenesis by Its Antioxidative Actions(Biochemistry)
- Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids
- Increase in the Free Radical Scavenging Activity of Ginseng by Heat-Processing(Pharmacognosy)
- Anti-aging Effects of Cyanidin under a Stress-Induced Premature Senescence Cellular System
- Radical Scavenging Activity and Inhibition of Advanced Glycation End Products(AGEs) Formation of Lespedeza Cuneata(The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)
- Attenuation of Renal Ischemia-Reperfusion Injury by Proanthocyanidin-Rich Extract from Grape Seeds
- The Protective Role of Chinese Prescription Kangen-karyu Extract on Diet-Induced Hypercholesterolemia in Rats(Pharmacognosy)
- The Beneficial Effects of Morroniside on the Inflammatory Response and Lipid Metabolism in the Liver of db/db Mice
- Effects of Egg Yolk Proteins on the Longitudinal Bone Growth of Adolescent Male Rats
- Protective Effect of Lipoic Acid against Methylglyoxal-Induced Oxidative Stress in LLC-PK_1 Cells
- Protective effect of Sanguisorbae Radix against peroxynitrite-mediated renal injury
- A Study on the Nitric Oxide Production-Suppressing Activity of Sanguisorbae Radix Components
- Beneficial Effects of Sanguisorbae Radix in Renal Dysfunction Caused by Endotoxin in Vivo
- Tinospora tuberculata Suppresses Nitric Oxide Synthesis in Mouse Macrophages
- First Indications Demonstrating the Preventive Effects of NZ-419, a Novel Intrinsic Antioxidant, on the Initiation and/or Progression of Chronic Renal Failure in Rats
- Modulation of Oxidative Stress and Melanogenesis by Proanthocyanidins
- Effects of a Component of Green Tea on the Proliferation of Vascular Smooth Muscle Cells
- Depressor Effect of Tannin in Green Tea on Rats with Renal Hypertension
- Effect of Tannins in Green Tea on the Urinary Methylguanidine Excretion in Rats Indicating a Possible Radical Scavenging Action
- γ-Aminobutyric Acid Specifically Inhibits Progression of Tubular Fibrosis and Atrophy in Nephrectomized Rats(Pharmacology)
- Influence of Amla (Emblica officinalis Gaertn.) on Hypercholesterolemia and Lipid Peroxidation in Cholesterol-Fed Rats
- Protective Effects of γ-Aminobutyric Acid in Rats with Streptozotocin-Induced Diabetes
- Study on the Components of Luobuma with Peroxynitrite-Scavenging Activity
- Confirmation that Luobuma ameliorates the deterioration of antioxidant defense in senescence-accelerated mice
- Chinese Prescription Kangen-karyu Ameliorates the Development of Diabetic Hepatic Damages via Regulating Oxidative Stress and Inflammation in the Liver of db/db Mice
- Examination of the Nitric Oxide Production-Suppressing Component in Tinospora tuberculata
- Protective Role of Glycyrrhizae Radix from Peroxynitrite-induced Renal Oxidative Damages
- Effects of Oriental medicines on the production of advanced glycation endproducts
- Effects of Green Tea Polyphenol on Cognitive and Acetylcholinesterase Activities
- Egg Yolk Soluble Protein Stimulates the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
- Egg Yolk Soluble Protein Stimulates the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
- Evaluation of Morroniside, Iridoid Glycoside from Corni Fructus, on Diabetes-Induced Alterations such as Oxidative Stress, Inflammation, and Apoptosis in the Liver of Type 2 Diabetic db/db Mice
- Protective Effects of the BuOH Fraction from Mustard Leaf in a Renal Ischemia-Reperfusion Model
- 7-O-Galloyl-D-sedoheptulose Attenuates Oxidative Stress-Induced Diabetic Injury via Decreasing Expression of Nuclear Factor-κB- and Apoptosis-Related Protein in the Liver
- Glycerol-Induced Renal Damage Improved by 7-O-Galloyl-D-sedoheptulose Treatment through Attenuating Oxidative Stress
- Anti-Diabetic Action of 7-O-Galloyl-D-sedoheptulose, a Polyphenol from Corni Fructus, through Ameliorating Inflammation and Inflammation-Related Oxidative Stress in the Pancreas of Type 2 Diabetics
- Modulation of Oxidative Stress by Proanthocyanidin in H2O2-Exposed Human Diploid Fibroblast Cells
- Protective Effects of Mustard Leaf (Brassica juncea) against Diabetic Oxidative Stress