The Chinese Prescription Wen-Pi-Tang Extract Delays Disease Onset in Amyotrophic Lateral Sclerosis Model Mice While Attenuating the Activation of Glial Cells in the Spinal Cord(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the selective loss of motor neurons. There is no effective treatment or drug against ALS, and the precise mechanisms leading to the selective loss of motor neurons are still unknown. We investigated the effect of a Chinese prescription, Wen-Pi-Tang, on the ALS model mouse SOD1^<G93A>. Although the oral administration of Wen-Pi-Tang extract to SOD1^<G93A> mice had no significant effect on body weight loss and survival time, Wen-Pi-Tang delayed disease onset. Therefore, we evaluated immunohistological changes in the spinal cord of SOD1^<G93A> mice during the early disease period, and found that Wen-Pi-Tang extract inhibited neuronal loss in the lumbar segment of the spinal cord of mice. Furthermore, increased astrocytes and microglial cells, which increase prior to neuronal loss, in spinal cords were significantly reduced in the Wen-Pi-Tang treated group. Since oxidative markers, heme oxygenase-1 and inducible nitric oxide synthase, in the spinal cord were also reduced as well as the change in microglia, the administration of Wen-Pi-Tang was thought to delay disease onset by inhibiting glial cell activation.
- 社団法人日本薬学会の論文
- 2009-03-01
著者
-
Yokozawa Takako
Institute of Natural Medicine, University of Toyama
-
Yokozawa Takako
Inst. Of Natural Medicine Univ. Of Toyama
-
Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
-
SEKIYA Michiko
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
-
ICHIYANAGI Takashi
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
-
IKESHIRO Yasumasa
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
-
Sekiya Michiko
Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences:institut
-
Ikeshiro Yasumasa
Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
-
Ichiyanagi Takashi
Faculty Of Applied Life Sciences Niigata University Of Pharmacy And Applied Life Sciences
-
Ichiyanagi Takashi
Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
関連論文
- Treatment with NZ-419 (5-Hydroxy-1-methylimidazoline-2,4-dione), a Novel Intrinsic Antioxidant, against the Progression of Chronic Kidney Disease at Stages 3 and 4 in Rats
- Effects of Heat-Processed Ginseng and Its Active Component Ginsenoside 20(S)-Rg3 on the Progression of Renal Damage and Dysfunction in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty Rats
- Efficacy-based identification of active component of hachimijiogan ameliorating diabetic nephropathy
- 7-O-Galloyl-D-sedoheptulose Is a Novel Therapeutic Agent against Oxidative Stress and Advanced Glycation Endproducts in the Diabetic Kidney(Pharmacognosy)
- Protective Effects of Morroniside Isolated from Corni Fructus against Renal Damage in Streptozotocin-Induced Diabetic Rats
- Protective Effect of Persimmon (Diospyros kaki) Peel Proanthocyanidin against Oxidative Damage under H_2O_2-Induced Cellular Senescence(Pharmacology)
- Hypolipidemic Effects of Sophora flavescens and Its Constituents in Poloxamer 407-Induced Hyperlipidemic and Cholesterol-Fed Rats(Pharmacognosy)
- Identification of Antidiabetic Effect of Iridoid Glycosides and Low Molecular Weight Polyphenol Fractions of Corni Fructus, a Constituent of Hachimi-jio-gan, in Streptozotocin-Induced Diabetic Rats
- Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes
- ESR Study on the Structure and Hydroxyl Radical-Scavenging Activity Relationships of Ginsenosides Isolated from Panax ginseng C. A. MEYER(Pharmacognosy)
- Study on the Hydroxyl Radical Scavenging Activity Changes of Ginseng and Ginsenoside-Rb_2 by Heat Processing(Pharmacognosy)
- Beneficial Effect of Corni Fructus, a Constituent of Hachimi-jio-gan, on Advanced Glycation End-product-Mediated Renal Injury in Streptozotocin-Treated Diabetic Rats
- Protective Effects of Broccoli (Brassica oleracea) against Oxidative Damage in Vitro and in Vivo
- Protective Effect of Sun Ginseng against Diabetic Renal Damage(Pharmacognosy)
- Mustard Leaf Suppresses Nitric Oxide Synthesis by Mouse Macrophages
- Protective Effects of Broccoli (Brassica oleracea) and Its Active Components against Radical-Induced Oxidative Damage
- Protective Effects of Mustard Leaf (Brassica juncea) against Diabetic Oxidative Stress
- Protective Effects of the BuOH Fraction from Mustard Leaf in a Renal Ischemia-Reperfusion Model
- Neuroprotective Effects of Kangen-karyu on Spatial Memory Impairment in an 8-Arm Radial Maze and Neuronal Death in the Hippocampal CA1 Region Induced by Repeated Cerebral Ischemia in Rats
- Protective Effects of a Neutral Polysaccharide Isolated from the Mycelium of Antrodia cinnamomea on Propionibacterium acnes and Lipopolysaccharide Induced Hepatic Injury in Mice
- The Effects of Glycine and L-Arginine on Heat Stability of Ginsenoside Rb_1(Pharmacognosy)
- The Chinese Prescription Wen-Pi-Tang Extract Delays Disease Onset in Amyotrophic Lateral Sclerosis Model Mice While Attenuating the Activation of Glial Cells in the Spinal Cord(Pharmacology)
- Protective Effect of Grape Seed Polyphenols against High Glucose-Induced Oxidative Stress
- Effects of Buckwheat in a Renal Ischemia-Reperfusion Model
- Effects of a Dan Shen component, magnesium lithospermate B, in nephrectomized rats
- Piceatannol Inhibits Melanogenesis by Its Antioxidative Actions(Biochemistry)
- Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids
- Increase in the Free Radical Scavenging Activity of Ginseng by Heat-Processing(Pharmacognosy)
- Anti-aging Effects of Cyanidin under a Stress-Induced Premature Senescence Cellular System
- Radical Scavenging Activity and Inhibition of Advanced Glycation End Products(AGEs) Formation of Lespedeza Cuneata(The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)
- Attenuation of Renal Ischemia-Reperfusion Injury by Proanthocyanidin-Rich Extract from Grape Seeds
- The Protective Role of Chinese Prescription Kangen-karyu Extract on Diet-Induced Hypercholesterolemia in Rats(Pharmacognosy)
- The Beneficial Effects of Morroniside on the Inflammatory Response and Lipid Metabolism in the Liver of db/db Mice
- Protective Effect of Lipoic Acid against Methylglyoxal-Induced Oxidative Stress in LLC-PK_1 Cells
- Protective effect of Sanguisorbae Radix against peroxynitrite-mediated renal injury
- A Study on the Nitric Oxide Production-Suppressing Activity of Sanguisorbae Radix Components
- Beneficial Effects of Sanguisorbae Radix in Renal Dysfunction Caused by Endotoxin in Vivo
- Tinospora tuberculata Suppresses Nitric Oxide Synthesis in Mouse Macrophages
- First Indications Demonstrating the Preventive Effects of NZ-419, a Novel Intrinsic Antioxidant, on the Initiation and/or Progression of Chronic Renal Failure in Rats
- Modulation of Oxidative Stress and Melanogenesis by Proanthocyanidins
- Simultaneous Comparison of Relative Reactivities of Twelve Major Anthocyanins in Bilberry towards Reactive Nitrogen Species
- Structural Dependence of HPLC Separation Pattern of Anthocyanins from Bilberry (Vaccinium myrtillus L.)
- Kinetic Comparisons of Anthocyanin Reactivities towards 2, 2'-Azobis (2-amidinopropane) (AAPH) Radicals, Hydrogen Peroxide and tert-Buthylhydroperoxide by Capillary Zone Electrophoresis
- Complete Assignment of Bilberry (Vaccinium myrtillus L.) Anthocyanins Separated by Capillary Zone Electrophoresis
- γ-Aminobutyric Acid Specifically Inhibits Progression of Tubular Fibrosis and Atrophy in Nephrectomized Rats(Pharmacology)
- Influence of Amla (Emblica officinalis Gaertn.) on Hypercholesterolemia and Lipid Peroxidation in Cholesterol-Fed Rats
- Protective Effects of γ-Aminobutyric Acid in Rats with Streptozotocin-Induced Diabetes
- Study on the Components of Luobuma with Peroxynitrite-Scavenging Activity
- Confirmation that Luobuma ameliorates the deterioration of antioxidant defense in senescence-accelerated mice
- Chinese Prescription Kangen-karyu Ameliorates the Development of Diabetic Hepatic Damages via Regulating Oxidative Stress and Inflammation in the Liver of db/db Mice
- Acid Mediated Hydrolysis of Blueberry Anthocyanins
- Comparison of Anthocyanin Distribution in Different Blueberry Sources by Capillary Zone Electrophoresis
- Examination of the Nitric Oxide Production-Suppressing Component in Tinospora tuberculata
- Protective Role of Glycyrrhizae Radix from Peroxynitrite-induced Renal Oxidative Damages
- Effects of Oriental medicines on the production of advanced glycation endproducts
- Evaluation of Morroniside, Iridoid Glycoside from Corni Fructus, on Diabetes-Induced Alterations such as Oxidative Stress, Inflammation, and Apoptosis in the Liver of Type 2 Diabetic db/db Mice
- A Study of Injection Molding (Analysis of the Partial Thermal Shrinkage in Rib Structures) : Solid-Mechanics, Strength of Materials
- Protective Effects of the BuOH Fraction from Mustard Leaf in a Renal Ischemia-Reperfusion Model
- 7-O-Galloyl-D-sedoheptulose Attenuates Oxidative Stress-Induced Diabetic Injury via Decreasing Expression of Nuclear Factor-κB- and Apoptosis-Related Protein in the Liver
- Glycerol-Induced Renal Damage Improved by 7-O-Galloyl-D-sedoheptulose Treatment through Attenuating Oxidative Stress
- Anti-Diabetic Action of 7-O-Galloyl-D-sedoheptulose, a Polyphenol from Corni Fructus, through Ameliorating Inflammation and Inflammation-Related Oxidative Stress in the Pancreas of Type 2 Diabetics
- Erratum: Simultaneous Comparison of Relative Reactivities of Twelve Major Anthocyanins in Bilberry towards Reactive Nitrogen Species [Chem. Pharm. Bull. 52(11): 1312-1315 (2004)]
- Modulation of Oxidative Stress by Proanthocyanidin in H2O2-Exposed Human Diploid Fibroblast Cells
- Protective Effects of Mustard Leaf (Brassica juncea) against Diabetic Oxidative Stress